Compounds binding to JMJD6 with antifibrotic activity
First Claim
1. A monoclonal antibody or a fragment thereof,wherein the monoclonal antibody or a fragment thereof binds to JMJD6,wherein the monoclonal antibody or a fragment thereof comprises a light chain variable region and a heavy chain variable region,wherein the light chain variable region comprises the following CDRs:
- QSILYSSNHKN (SEQ ID NO;
42), WASTRESGVP (SEQ ID NO;
43), and HQYLSS (SEQ ID NO;
44); and
wherein the heavy chain variable region comprises the following CDRs;
GFSLSSYG (SEQ ID NO;
45), IWRSGNT (SEQ ID NO;
46), and AKNFRYDVGSWFAY (SEQ ID NO;
47).
1 Assignment
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Accused Products
Abstract
The present invention relates to the interaction between JMJD6 protein and collagen and to the possibility of inhibiting this interaction for the prevention and treatment of fibrosis and of tumor metastases. The invention further relates to a compound that is able to block the interaction between collagen and JMJD6 protein, in particular the invention relates to a new monoclonal antibody that recognizes JMJD6 and is able to block this interaction.
2 Citations
11 Claims
-
1. A monoclonal antibody or a fragment thereof,
wherein the monoclonal antibody or a fragment thereof binds to JMJD6, wherein the monoclonal antibody or a fragment thereof comprises a light chain variable region and a heavy chain variable region, wherein the light chain variable region comprises the following CDRs: - QSILYSSNHKN (SEQ ID NO;
42), WASTRESGVP (SEQ ID NO;
43), and HQYLSS (SEQ ID NO;
44); andwherein the heavy chain variable region comprises the following CDRs;
GFSLSSYG (SEQ ID NO;
45), IWRSGNT (SEQ ID NO;
46), and AKNFRYDVGSWFAY (SEQ ID NO;
47). - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 10, 11)
- QSILYSSNHKN (SEQ ID NO;
-
8. A hybridoma deposited with the Autorità
- Internazionale di Deposito (AID) Centro di Biotecnologie Avanzate (CBA)—
Interlab Cell Line Collection (ICLC) of Genoa (Italy), access number PD 15001.
- Internazionale di Deposito (AID) Centro di Biotecnologie Avanzate (CBA)—
Specification