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Corneal epithelioid cells derived from surface ectodermal cells

  • US 10,457,913 B2
  • Filed: 01/12/2016
  • Issued: 10/29/2019
  • Est. Priority Date: 01/13/2015
  • Status: Active Grant
First Claim
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1. An in vitro or ex vivo method for producing a keratin-12 positive human corneal epithelioid cell, comprising:

  • introducing a lentiviral vector comprising nucleic acids encoding PAX6, KLF4, and OCT4 into a human epithelial cell,wherein expression of the lentiviral vector induces the production of a keratin 12-positive human corneal epithelioid cell.

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