UNA oligomers for therapeutics with prolonged stability
First Claim
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1. A ribonucleotide oligomer comprising one or more 2′
- -3′
-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers, wherein the oligomer is a duplex having a ribonucleotide sense strand and ribonucleotide antisense strand, wherein one or more of the 2′
-3′
-seco-nucleomonomers are in the antisense strand in positions 1-8 counted from the 5′
end, and wherein the 2′
-3′
-seco-nucleomonomers are monomer D
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Abstract
This invention provides UNA oligomers for therapeutics having prolonged stability. The UNA oligomers can be composed of one or more 2′-3′-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers. Embodiments include UNA oligomers with phosphorothioate or boranophosphate intermonomer linkages. The UNA oligomers can be used for therapeutics that target oligonucleotides, nucleic acids, or RNAs to reduce their activity.
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Citations
20 Claims
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1. A ribonucleotide oligomer comprising one or more 2′
- -3′
-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers, wherein the oligomer is a duplex having a ribonucleotide sense strand and ribonucleotide antisense strand, wherein one or more of the 2′
-3′
-seco-nucleomonomers are in the antisense strand in positions 1-8 counted from the 5′
end, and wherein the 2′
-3′
-seco-nucleomonomers are monomer D - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- -3′
Specification