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Methods for overcoming glucocorticoid resistance and for determining glucocorticoid resistance potential in cancer

  • US 10,457,946 B2
  • Filed: 09/16/2014
  • Issued: 10/29/2019
  • Est. Priority Date: 09/16/2013
  • Status: Active Grant
First Claim
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1. A method of sensitizing a cancer cell to glucocorticoid-induced apoptosis or cell death, wherein said cell is resistant to glucocorticoid-induced apoptosis or cell death and wherein the expression level of CASP1 gene and/or NLRP3 gene in said cell is increased as compared to a corresponding glucocorticoid-sensitive control, comprising contacting the cell with an effective amount of an inhibitor of CASP1.

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