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Modified type A DNA polymerases

  • US 10,457,968 B2
  • Filed: 11/03/2009
  • Issued: 10/29/2019
  • Est. Priority Date: 11/03/2008
  • Status: Active Grant
First Claim
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1. A modified Taq DNA polymerase that:

  • (i) has an amino acid sequence that has at least 95% amino acid sequence identity with wild type Taq DNA polymerase set out in SEQ ID NO.;

    1, but includes a substitution relative to SEQ ID NO;

    1 at a position corresponding to position 507 of SEQ ID NO.;

    1, which substitution is E507K; and

    (ii) has polymerase activity in catalyzing DNA template-directed synthesis of a DNA polynucleotide, which activity has increased salt-tolerance relative to the wild type Taq DNA polymerase of SEQ ID NO.;

    1.

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