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In vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment

  • US 10,458,891 B2
  • Filed: 08/19/2015
  • Issued: 10/29/2019
  • Est. Priority Date: 08/20/2014
  • Status: Active Grant
First Claim
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1. An in vitro method for analyzing the behaviour of substances in simulated physiological environment, the method comprising the steps of:

  • providing a first fluid, a gel matrix and a second fluid;

    separating the first fluid and the gel matrix by at least one first semi-permeable membrane;

    separating the gel matrix and the second fluid by at least one second semi-permeable membrane;

    injecting a substance into the first fluid;

    letting the substance migrate from the first fluid through the at least one first semi-permeable membrane, through the gel matrix, through the at least one second semi-permeable membrane and into the second fluid; and

    determining clearance of the substance from the first fluid, wherein the first fluid is vitreous humor and the second fluid is a buffer solution.

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