Chemical sensor array having multiple sensors per well
First Claim
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1. A device comprising:
- a material defining a reaction region, the reaction region having a bottom surface and configured to receive a solution having an analyte;
a plurality of chemically-sensitive field effect transistors having a common floating gate in communication with the reaction region; and
a circuit including a plurality of row lines and a plurality of column lines, a first chemically-sensitive field effect transistor of the plurality of chemically-sensitive field effect transistors and a second chemically-sensitive field effect transistor of the plurality of chemically-sensitive field effect transistors responsive to a bias voltage on a row line of the plurality of row lines, in response to the bias voltage on the row line, the first chemically-sensitive field effect transistor providing a first output signal on a first column line and the second chemically-sensitive field effect transistor providing a second output signal on a second column line, each of the first and second output signals indicating a presence of the analyte within the solution;
wherein the plurality of chemically-sensitive field effect transistors communicate with a reference electrode and wherein the reference electrode contacts the solution.
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Abstract
In one embodiment, a device is described. The device includes a material defining a reaction region. The device also includes a plurality of chemically-sensitive field effect transistors have a common floating gate in communication with the reaction region. The device also includes a circuit to obtain respective output signals from the chemically-sensitive field effect transistors indicating an analyte within the reaction region.
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Citations
16 Claims
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1. A device comprising:
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a material defining a reaction region, the reaction region having a bottom surface and configured to receive a solution having an analyte; a plurality of chemically-sensitive field effect transistors having a common floating gate in communication with the reaction region; and a circuit including a plurality of row lines and a plurality of column lines, a first chemically-sensitive field effect transistor of the plurality of chemically-sensitive field effect transistors and a second chemically-sensitive field effect transistor of the plurality of chemically-sensitive field effect transistors responsive to a bias voltage on a row line of the plurality of row lines, in response to the bias voltage on the row line, the first chemically-sensitive field effect transistor providing a first output signal on a first column line and the second chemically-sensitive field effect transistor providing a second output signal on a second column line, each of the first and second output signals indicating a presence of the analyte within the solution; wherein the plurality of chemically-sensitive field effect transistors communicate with a reference electrode and wherein the reference electrode contacts the solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus, comprising:
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a group of two or more chemical sensors coupled to a reaction region via a common floating gate, the reaction region configured to receive a solution containing an analyte; a reference electrode coupled to the group of two or more chemical sensors, the reference electrode configured to contact the solution; a select circuitry including a row line to select at least two chemical sensors of the two or more chemical sensors; an output circuit for accessing the group of chemical sensors via a plurality of column lines; and a controller to; in response to a bias voltage on the row line, a first chemical sensor of the at least two chemical sensors providing a first output signal on a first column line of the plurality of column lines and the second chemical sensor of the at least two chemical sensors providing a second output signal on a second column line of the plurality of column lines, the first and second output signals indicating a presence of an analyte in the solution; and calculate a resultant output signal for the group of chemical sensors based on one or more of the first and second output signals.
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15. A device comprising:
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a plurality of reaction chambers configured to receive a solution; a plurality of chemically-sensitive field effect transistors, each of the plurality of chemically-sensitive field effect transistors in communication with one of the plurality of reaction chambers, at least two chemically-sensitive field effect transistors having a common floating gate in communication with one reaction chamber of the plurality of reaction chambers, each of the at least two of the plurality of chemically-sensitive field effect transistors is responsive to a bias voltage on a row line, a first of the at least two of the plurality of chemically-sensitive field effect transistors coupled to a first column output line, a second of the at least of the plurality of chemically-sensitive field effect transistors coupled to a second column output line different from the first column output line, the first and second column output lines providing the separate output signals to a column output circuitry of a circuit; the circuit to obtain the separate output signals via first and second column output lines from at least two of the plurality of chemically-sensitive field effect transistors when a chemical reaction is detected proximal to a corresponding reaction chamber, the chemical reaction to indicate a presence of an analyte within the corresponding reaction chamber; and a reference electrode to communicate with at least two of the plurality of chemically-sensitive field effect transistors, the reference electrode configured to contact the solution. - View Dependent Claims (16)
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Specification