System and method for magnetic resonance imaging with prospective motion control

• US 10,459,058 B2
• Filed: 04/16/2015
• Issued: 10/29/2019
• Est. Priority Date: 04/18/2014
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Van Der Kouwe, Andre J. W., Tisdall, Matthew D.
• Primary Examiner(s): Arana, Louis M
• Application Number:
  US15/301,860
• Publication Number:
  US 20170219674A1
• Time in Patent Office: 1,657 Days
• Field of Search: 324306, 324307, 324309
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/483 with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
• CPC Class Codes: G01R 33/5613 Generating steady state signals, e.g. low flip angle sequences [FLASH]
• CPC Class Codes: G01R 33/5616 using gradient refocusing, e.g. EPI
• CPC Class Codes: G01R 33/56509 due to motion, displacement or flow, e.g. gradient moment nulling G01R33/567 takes precedence
• CPC Class Codes: G01R 33/5673 Gating or triggering based on a physiological signal other than an MR signal, e.g. ECG gating or motion monitoring using optical systems for monitoring the motion of a fiducial marker

Abstract

A system and method for directing an MRI system to form echo signals from spins in a volume-of-interest (VOI) includes creating an integrated pulse sequence that integrates a volume navigator pulse sequence with an imaging pulse sequence by coordinating a navigator TR with an imaging TR to preserve a steady state of magnetization in the VOI associated with the imaging pulse sequence. The integrated pulse sequence includes performing the imaging pulse sequence to acquire imaging data from the VOI, performing the navigator pulse sequence to acquire navigator data VOI, processing the navigator data to generate motion estimates of motion in the VOI, creating an updated imaging pulse sequence that prospectively corrects for the motion in the VOI using the motion estimates, and repeating these steps using the updated imaging pulse sequence.

Claims

1. A method for directing a magnetic resonance imaging (MRI) system to form echo signals from spins in a volume-of-interest (VOI), the steps of the method comprising:

a) selecting an imaging pulse sequence that utilizes gradient fields to generate transverse magnetization to acquire imaging data from the VOI during an imaging repetition time (TR);

b) selecting a volume navigator pulse sequence that uses an echo-planar imaging (EPI) technique to acquire navigator data from the VOI during a navigator TR;

c) creating an integrated pulse sequence that integrates the volume navigator pulse sequence with the imaging pulse sequence by coordinating the navigator TR with the imaging TR to preserve a steady state of magnetization in the VOI associated with the imaging pulse sequence;

d) performing, with the MRI system, the integrated pulse sequence by;

i) performing the imaging pulse sequence to acquire imaging data from the VOI;

ii) performing the navigator pulse sequence to acquire navigator data VOI;

iii) processing the navigator data to generate motion estimates of motion in the VOI;

iv) creating an updated imaging pulse sequence that prospectively corrects for the motion in the VOI using the motion estimates;

v) repeating steps i) through iv) using the updated imaging pulse sequence; and

e) reconstructing the imaging data to form at least one three-dimensional image of the VOI.

2. The method of claim 1 wherein the volume navigator pulse sequence includes a vNavs pulse sequence.

3. The method of claim 1 wherein the imaging pulse sequence includes a gradient echo pulse sequence.

4. The method of claim 1 wherein the integrated pulse sequence includes the EPI technique and a gradient echo technique.

5. The method of claim 1 wherein the navigator TR is matched with the imaging TR.

6. The method of claim 1 wherein the VOI includes a head of a subject and the volume navigator pulse sequence is configured to acquire navigator data from the head.

7. A magnetic resonance imaging (MRI) system, comprising:

a magnet system configured to generate a static magnetic field about at least a volume of interest (VOI) of a subject arranged in the MRI system;

a gradient coil system configured to establish at least one magnetic gradient field with respect to the static magnetic field;

a radio frequency (RF) system configured to deliver excitation pulses to the subject and acquire data from the subject;

a computer system programmed to;

receive an indication of an imaging pulse sequence that utilizes gradient fields to generate transverse magnetization to acquire imaging data from the VOI during an imaging repetition time (TR);

receive an indication of a volume navigator pulse sequence that uses an echo-planar imaging (EPI) technique to acquire navigator data from the VOI during a navigator TR;

create an integrated pulse sequence that integrates the volume navigator pulse sequence with the imaging pulse sequence by coordinating the navigator TR with the imaging TR to preserve a steady state of magnetization in the VOI associated with the imaging pulse sequence;

control the gradient coil system and the RF system to perform the integrated pulse sequence by;

i) performing the imaging pulse sequence to acquire imaging data from the VOI;

ii) performing the navigator pulse sequence to acquire navigator data VOI;

iii) processing the navigator data to generate motion estimates of motion in the VOI;

iv) creating an updated imaging pulse sequence that prospectively corrects for the motion in the VOI using the motion estimates;

v) repeating steps i) through iv) using the updated imaging pulse sequence; and

reconstruct the imaging data to form at least one three-dimensional image of the VOI.

8. The system of claim 7 wherein the volume navigator pulse sequence includes a vNavs pulse sequence.

9. The system of claim 7 wherein the imaging pulse sequence includes a gradient echo pulse sequence.

10. The system of claim 7 wherein the integrated pulse sequence includes the EPI technique and a gradient echo technique.

11. The system of claim 7 wherein the navigator TR is matched with a TR of the imaging pulse sequence.

12. The system of claim 7 wherein the VOI includes a head of a subject and the volume navigator pulse sequence is configured to acquire navigator data from the head.

13. A method for directing a magnetic resonance imaging (MRI) system to form echo signals from spins in a volume-of-interest (VOI), the steps of the method comprising:

a) selecting an imaging pulse sequence that utilizes gradient fields to generate transverse magnetization to acquire imaging data from the VOI during an imaging repetition time (TR);

b) selecting a volume navigator pulse sequence that uses an echo-planar imaging (EPI) technique to acquire navigator data from the VOI during a navigator TR;

c) creating an integrated pulse sequence that uses a common radio frequency (RF) pulse for the volume navigator pulse sequence and the imaging pulse sequence to preserve a steady state of magnetization in the VOI;

d) performing, with the MRI system, the integrated pulse sequence by;

i) performing the imaging pulse sequence to acquire imaging data from the VOI;

ii) performing the navigator pulse sequence to acquire navigator data VOI;

iii) processing the navigator data to generate motion estimates of motion in the VOI;

iv) creating an updated imaging pulse sequence that prospectively corrects for the motion in the VOI using the motion estimates;

v) repeating steps i) through iv) using the updated imaging pulse sequence; and

e) reconstructing the imaging data to form at least one three-dimensional image of the VOI.

14. The method of claim 13 wherein the volume navigator pulse sequence includes a vNavs pulse sequence.

15. The method of claim 13 wherein the imaging pulse sequence includes a gradient echo pulse sequence.

16. The method of claim 13 wherein the integrated pulse sequence includes the EPI technique and a gradient echo technique.

17. The method of claim 13 wherein the navigator TR is matched with the imaging TR.

18. The method of claim 13 wherein the VOI includes a head of a subject and the volume navigator pulse sequence is configured to acquire navigator data from the head.