Medical therapeutic apparatus, method of using medical therapeutic apparatus, and method of applying reactive gas

• US 10,462,892 B2
• Filed: 06/15/2018
• Issued: 10/29/2019
• Est. Priority Date: 06/16/2017
• Status: Active Grant

• Current Assignee: Sekisui Chemical Company Limited (Sekisui)
• Original Assignee: Sekisui Chemical Company Limited (Sekisui)
• Inventors: Oshita, Takaya, Uehara, Tsuyoshi, Nagahara, Yu, Takikawa, Yoshishige
• Primary Examiner(s): A, Minh D
• Application Number:
  US16/333,462
• Publication Number:
  US 20190215941A1
• Time in Patent Office: 501 Days
• CPC Class Codes: A61B 18/0218 with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip
• CPC Class Codes: A61B 18/042 using additional gas becoming plasma
• CPC Class Codes: A61B 2018/00017 with gas
• CPC Class Codes: A61B 2018/00029 open
• CPC Class Codes: A61B 2018/00714 Temperature
• CPC Class Codes: A61B 2018/00744 Fluid flow
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00821 measured by a thermocouple
• CPC Class Codes: A61C 1/00 Dental machines for boring or cutting ; General features of dental machines or apparatus, e.g. hand-piece design
• CPC Class Codes: A61C 17/022 Air-blowing devices , e.g. with means for heating the air
• CPC Class Codes: A61F 2007/006 of gas
• CPC Class Codes: A61F 2007/0064 of gas
• CPC Class Codes: A61F 2007/0087 Hand-held applicators
• CPC Class Codes: A61F 7/0085 Devices for generating hot or cold treatment fluids
• CPC Class Codes: A61L 2/0011 using physical methods
• CPC Class Codes: A61L 2/14 Plasma, i.e. ionised gases
• CPC Class Codes: A61L 2202/11 Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
• CPC Class Codes: A61N 1/44 Applying ionised fluids ion generators H01J37/00
• CPC Class Codes: B01J 19/087 employing electric or magnetic energy
• CPC Class Codes: H05H 1/2406 using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
• CPC Class Codes: H05H 1/2418 : the electrodes being embedded in the dielectric
• CPC Class Codes: H05H 1/2443 : the plasma fluid flowing through a dielectric tube
• CPC Class Codes: H05H 1/3463 : Oblique nozzles
• CPC Class Codes: H05H 1/46 : using applied electromagnetic fields, e.g. high frequency or microwave energy H05H1/26 takes precedence
• CPC Class Codes: H05H 2245/32 : Surgery, e.g. scalpels, blades or bistoury; Treatments inside the body
• CPC Class Codes: H05H 2245/34 : Skin treatments, e.g. disinfection or wound treatment

Abstract

The present invention discloses a medical therapeutic apparatus (100) which generates plasma and blows out an reactive gas generated by the generated plasma toward a target object from an outlet, wherein a temperature of the reactive gas at a target surface positioned at a distance of 1 mm or more and 10 mm or less from the outlet is 40° C. or less, and a radical concentration is 0.1 to 300 μmol/L as determined by a hydroxy radical concentration measuring method comprising applying the reactive gas to 0.4 mL of a 0.2 mol/L solution of DMPO (5,5-dimethyl-1-pyrroline-N-oxide) for 30 seconds with a distance from the outlet to a liquid surface of the solution being 5.0 mm, and measuring a hydroxyl radical concentration of the resulting solution by electron spin resonance (ESR) method.

Claims

1. A medical therapeutic apparatus which generates plasma and blows out a reactive gas generated by the generated plasma toward a target object from an outlet,

wherein a temperature of the reactive gas at a target surface positioned at a distance of 1 mm or more and 10 mm or less from the outlet is 40°

C. or less, and at least one of the following requirements is satisfied;

(1) a hydroxyl radical concentration is 0.1 to 300 μ

mol/L, and (2) a singlet oxygen concentration is 0.1 to 300 μ

mol/L,

wherein the hydroxy radical concentration is measured by a method comprising applying the reactive gas to 0.4 mL of a 0.2 mol/L solution of DMPO (5,5-dimethyl-1-pyrroline-N-oxide) for 30 seconds with a distance from the outlet to a liquid surface of the solution being 5.0 mm, and measuring a hydroxyl radical concentration of the resulting solution by electron spin resonance (ESR) method, and

the singlet oxygen concentration is measured by a method comprising applying the reactive gas to 0.4 mL of a 0.1 mol/L solution of TPC (2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide) for 30 seconds with a distance from the outlet to a liquid surface of the solution being 5.0 mm, and measuring a singlet oxygen concentration of the resulting solution by electron spin resonance (ESR) method.

2. The medical therapeutic apparatus according to claim 1, which is for dental use.

3. A method of using a medical therapeutic apparatus, comprising providing the medical therapeutic apparatus according to claim 2, and blowing out the reactive gas to a target object using the medical therapeutic apparatus.

4. A method of using a medical therapeutic apparatus, comprising providing the medical therapeutic apparatus according to claim 1, and blowing out the reactive gas to a target object using the medical therapeutic apparatus.

5. A method of applying an reactive gas to a target object, excluding medical practice on human body, comprising applying a voltage to a plasma generating gas to generate plasma, and applying a reactive gas generated by the plasma to a target object selected from a cell, a living tissue and a whole body of an organism, to thereby promote cleaning, activation or healing of abnormalities of the target object,

wherein a temperature of the reactive gas at a target surface positioned at a distance of 1 mm or more and 10 mm or less from the outlet is 40°

C. or less, and at least one of the following requirements is satisfied;

(1) a hydroxyl radical concentration is 0.1 to 300 μ

mol/L, and

     12) a singlet oxygen concentration is 0.1 to 300 μ

mol/L,

wherein the hydroxy radical concentration is measured by a method comprising applying the reactive gas to 0.4 mL of a 0.2 mol/L solution of DMPO (5,5-dimethyl-1-pyrroline-N-oxide) for 30 seconds with a distance from the outlet to a liquid surface of the solution being 5.0 mm, and measuring a hydroxyl radical concentration of the resulting solution by electron spin resonance (ESR) method, and

the singlet oxygen concentration is measured by a method comprising applying the reactive gas to 0.4 mL of a 0.1 mol/L solution of TPC (2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide) for 30 seconds with a distance from the outlet to a liquid surface of the solution being 5.0 mm, and measuring a singlet oxygen concentration of the resulting solution by electron spin resonance (ESR) method.

6. The method according to claim 5, wherein the plasma generating gas contains nitrogen gas as a main component.

7. The method according to claim 6, wherein the plasma generating gas has an oxygen concentration of 1% by volume or less.

8. The method according to claim 5, wherein the plasma generating gas has an oxygen concentration of 1% by volume or less.