Determination of tissue oxygenation in vivo
First Claim
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1. A system for determining muscle oxygenation in a body, the system comprising:
- a probe comprising a housing having a housing face configured to abut the body;
a processor connected to control a first light source operable to emit light at a first radiant flux in a visible wavelength range from a plurality of first emission locations on the housing face, and further connected to control a second light source operable to emit light at a second radiant flux in a near-infrared wavelength range from one or more second emission locations on the housing face such that the visible light emitted by the first light source and the near-infrared light emitted by the second light source are directed into the abutting body, wherein the first radiant flux is greater than the second radiant flux; and
a light detector system configured to receive light from the body at a receiving location on the housing face and to transmit spectral information characterizing the received light to the processor;
wherein the processor is configured to calculate a muscle oxygenation based on the spectral information transmitted by the light detector system; and
furtherwherein the plurality of first emission locations and the one or more second emission locations are disposed along a circular arc centered on the receiving location.
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Abstract
A system and method for noninvasively determining the oxygenation of a tissue, for example, a muscle, in vivo uses optical methods to optically interrogate the tissue in both a visible wavelength range and a near infrared (NIR) wavelength range. The illuminating light is sculpted in intensity to approximately match the absorbance spectrum, for example, with the visible light having an intensity an order of magnitude greater than the NIR light. Training data is obtained from healthy patients in both the visible and NIR ranges simultaneously and used to calculate muscle oxygenation.
142 Citations
21 Claims
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1. A system for determining muscle oxygenation in a body, the system comprising:
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a probe comprising a housing having a housing face configured to abut the body; a processor connected to control a first light source operable to emit light at a first radiant flux in a visible wavelength range from a plurality of first emission locations on the housing face, and further connected to control a second light source operable to emit light at a second radiant flux in a near-infrared wavelength range from one or more second emission locations on the housing face such that the visible light emitted by the first light source and the near-infrared light emitted by the second light source are directed into the abutting body, wherein the first radiant flux is greater than the second radiant flux; and a light detector system configured to receive light from the body at a receiving location on the housing face and to transmit spectral information characterizing the received light to the processor; wherein the processor is configured to calculate a muscle oxygenation based on the spectral information transmitted by the light detector system; and
furtherwherein the plurality of first emission locations and the one or more second emission locations are disposed along a circular arc centered on the receiving location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system for detecting circulatory shock comprising:
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a probe comprising a housing having a housing face configured to abut a body; a processor connected to control a first light source operable to emit light at a first radiant flux in a visible wavelength range from a plurality of first emission locations on the housing face, and further connected to control a second light source operable to emit light at a second radiant flux in a near-infrared wavelength range from one or more second emission locations on the housing face such that the visible light emitted by the first light source and the near-infrared light emitted by the second light source are directed into the abutting body, wherein the first radiant flux is greater than the second radiant flux; and a light detector system configured to receive light from the body at a receiving location on the housing face and to transmit spectral information characterizing the received light to the processor; wherein the plurality of first emission locations and the one or more second emission locations are disposed along a circular arc centered on the receiving location; and
furtherwherein the processor is configured to calculate a muscle oxygenation based on the spectral information transmitted by the light detector system, and to activate an alert if the calculated muscle oxygenation is below a predetermined threshold, thereby indicating a potential clinical concern for circulatory shock. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification