System, method, and computer readable medium for dynamic insulin sensitivity in diabetic pump users
First Claim
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1. A method of treating diabetes comprising:
- measuring interstitial fluid glucose concentration using a glucose monitor;
receiving insulin delivery data to reconstruct historical insulin concentration of a patient;
determining patient insulin sensitivity based on the measured interstitial fluid glucose concentration, the insulin delivery data, an estimated glucose rate of appearance, and an estimated insulin concentration; and
determining a diabetes treatment regime specific to the patient at a specific time based on the determined patient insulin sensitivity, wherein the estimated glucose rate of appearance is determined from a meal compartment including a first meal absorption model, and a second meal absorption model, such that the first meal absorption model is faster than the second meal absorption model, and the first and second meal absorption models are based on an adaptation of a Kalman filtering process.
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Abstract
A technique for treating diabetes that recognizes patient insulin sensitivity is a time-varying physiological parameter. The described techniques for treating diabetes include measuring interstitial fluid glucose concentration, reading insulin delivery data, determining patient insulin sensitivity based on the interstitial fluid glucose concentration and insulin delivery data, and a time-varying physiological parameter, and dispensing an insulin dose from an insulin delivery device based on the determined patient insulin sensitivity.
34 Citations
13 Claims
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1. A method of treating diabetes comprising:
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measuring interstitial fluid glucose concentration using a glucose monitor; receiving insulin delivery data to reconstruct historical insulin concentration of a patient; determining patient insulin sensitivity based on the measured interstitial fluid glucose concentration, the insulin delivery data, an estimated glucose rate of appearance, and an estimated insulin concentration; and determining a diabetes treatment regime specific to the patient at a specific time based on the determined patient insulin sensitivity, wherein the estimated glucose rate of appearance is determined from a meal compartment including a first meal absorption model, and a second meal absorption model, such that the first meal absorption model is faster than the second meal absorption model, and the first and second meal absorption models are based on an adaptation of a Kalman filtering process. - View Dependent Claims (2, 3, 4)
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5. A method for determining an insulin dose based on patient insulin sensitivity, the method comprising:
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receiving interstitial fluid glucose concentration measurements of a glucose monitor; receiving insulin delivery data to reconstruct historical insulin concentration of a patient; determining patient insulin sensitivity based on the received interstitial fluid glucose concentration measurements, the received insulin pump data, an estimated glucose rate of appearance, and an estimated insulin concentration; and determining an insulin dose based on the determined patient insulin sensitivity that is specific to a patient, wherein the estimated glucose rate of appearance is determined from a meal compartment including a first meal absorption model, and a second meal absorption model, such that the first meal absorption model is faster than the second meal absorption model, and the first and second meal absorption models are based on an adaptation of a Kalman filtering process. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13)
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Specification