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Selective oxidation of 5-methylcytosine by TET-family proteins

  • US 10,465,234 B2
  • Filed: 10/24/2018
  • Issued: 11/05/2019
  • Est. Priority Date: 09/26/2008
  • Status: Active Grant
First Claim
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1. A method comprising:

  • administering to a subject, an agent that modulates activity of an enzyme that mediates conversion of a methylated cytosine residue to a modified base, wherein said subject has a cancer or is at risk of developing said cancer, wherein said modified base comprises a hydroxymethylated cytosine residue and wherein said agent comprises a siRNA.

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