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Lowering blood glucose

  • US 10,471,104 B2
  • Filed: 09/18/2018
  • Issued: 11/12/2019
  • Est. Priority Date: 07/20/2009
  • Status: Active Grant
First Claim
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1. A method for lowering blood glucose levels in a mammal comprising:

  • (a) differentiating pancreatic endoderm cells in a medium comprising an exogenous retinoid to obtain a population of pancreatic endocrine precursor cells expressing insulin, NKX6.1 and PDX1, but not expressing CDX2; and

    (b) transplanting the population of pancreatic endocrine precursor cells of step (a) into the liver, natural pancreas, renal subcapsular space, omentum, peritoneum, subserosal space, intestine, or a subcutaneous pocket of the mammal, wherein the pancreatic endocrine precursor cells express insulin, lower the blood glucose levels in the mammal, and are protected from host immune response when transplanted.

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