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Hetero-pores

  • US 10,472,673 B2
  • Filed: 02/17/2016
  • Issued: 11/12/2019
  • Est. Priority Date: 02/19/2015
  • Status: Active Grant
First Claim
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1. A hetero-oligomeric pore derived from Msp which comprises a narrowing having a net negative charge, wherein the hetero-oligomeric pore comprises at least one monomer comprising a narrowing forming region comprising an amino acid sequence having at least one amino acid substitution from a non-negatively charged amino acid to a negatively charged amino acid compared with an amino acid sequence of a reference narrowing forming region, wherein the reference narrowing forming region corresponds to amino acids 83 to 111 of SEQ ID NO:

  • 2 and has the following substitutions;

    D90N, D91N, and D93N, and wherein none of the remaining monomers of the hetero-oligomeric pore has a sequence as set forth in SEQ ID NO;

    2.

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