Method and apparatus for analyte measurements using calibration sets
First Claim
1. An analyte detection system comprising:
- a fluidic system configured to withdraw a fluid sample from a fluid source and direct the withdrawn sample to a sample container;
a sensor system configured to interface with the sample held in the sample container to obtain a measurement of an analyte in the sample;
a hardware processor system configured to execute stored program instructions such that the analyte detection system;
accesses one or more calibration sets each usable to estimate a concentration of the analyte in the sample;
accesses the obtained measurement of the analyte in the sample;
determines, for each of the one or more calibration sets, whether the calibration set is eligible to estimate concentration of the analyte from the measurement of the sample by;
calculating a respective reconstructed measurement of the analyte in the sample based on the calibration set;
obtaining a metric based on a comparison of the reconstructed measurement of the analyte to the obtained measurement; and
comparing the obtained metric to a prediction eligibility threshold; and
determines an estimated concentration of the analyte in the sample based at least in part on the obtained measurement of the analyte in the sample and the calibration sets determined to be eligible; and
a display device configured to (i) display the estimated concentration if at least one of the one or more calibration sets is determined to be eligible to estimate concentration of the analyte or (ii) provide notification if none of the one or more calibration sets is determined to be eligible to estimate concentration of the analyte.
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Accused Products
Abstract
Examples of methods and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. In one example, the method can reduce the error in the estimation of analyte concentration in the presence of interferents. The method can include the use of one or more calibration set to determine analyte concentration. From a sample measurement, each calibration set can be tested to determine if it is eligible to estimate the analyte concentration in the sample. An estimate of analyte concentration can then be produced, based at least in part on the eligible calibration sets and on the sample measurement. In some implementations, if no calibration sets are eligible, an action is taken such as not outputting an estimate, displaying an alarm or alert, or providing a notification.
177 Citations
22 Claims
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1. An analyte detection system comprising:
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a fluidic system configured to withdraw a fluid sample from a fluid source and direct the withdrawn sample to a sample container; a sensor system configured to interface with the sample held in the sample container to obtain a measurement of an analyte in the sample; a hardware processor system configured to execute stored program instructions such that the analyte detection system; accesses one or more calibration sets each usable to estimate a concentration of the analyte in the sample; accesses the obtained measurement of the analyte in the sample; determines, for each of the one or more calibration sets, whether the calibration set is eligible to estimate concentration of the analyte from the measurement of the sample by; calculating a respective reconstructed measurement of the analyte in the sample based on the calibration set; obtaining a metric based on a comparison of the reconstructed measurement of the analyte to the obtained measurement; and comparing the obtained metric to a prediction eligibility threshold; and determines an estimated concentration of the analyte in the sample based at least in part on the obtained measurement of the analyte in the sample and the calibration sets determined to be eligible; and a display device configured to (i) display the estimated concentration if at least one of the one or more calibration sets is determined to be eligible to estimate concentration of the analyte or (ii) provide notification if none of the one or more calibration sets is determined to be eligible to estimate concentration of the analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification