Cellular extracts

• US 10,478,461 B2
• Filed: 06/18/2018
• Issued: 11/19/2019
• Est. Priority Date: 05/11/2006
• Status: Active Grant

• Current Assignee: Regenics AS
• Original Assignee: Regenics AS
• Inventors: Gammelsaeter, Runhild, Remmereit, Jan
• Primary Examiner(s): Bertoglio, Valarie E
• Application Number:
  US16/011,134
• Publication Number:
  US 20180303880A1
• Time in Patent Office: 519 Days
• CPC Class Codes: A61K 2800/805 Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
• CPC Class Codes: A61K 35/60 Fish, e.g. seahorses; Fish eggs
• CPC Class Codes: A61K 35/65 Amphibians, e.g. toads, frogs, salamanders or newts
• CPC Class Codes: A61K 8/987 of species other than mammals or birds
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/12 Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

Claims

1. A method of improving wound healing in a human subject, comprising:

applying a composition comprising a trout egg cellular extract having a protein content of from about 210-270 mg/ml and an RNA content from about 3.51 to 4.68 mg/ml to a wound of said subject under conditions such wound healing is improved, wherein said improvement is selected from the group consisting of faster drying, faster reepithelialization, reduced inflammation, faster contraction, earlier remodeling, reduction in scar tissue and improved visual appearance of the wound and combinations thereof.

2. The method of claim 1, wherein said composition is applied to a wound in the skin of said subject.

3. The method of claim 1, wherein said composition is provided in a cream, gel, emulsion, ointment, spray, powder or lotion.

4. The method of claim 1, wherein said trout egg extract is a cytoplasmic extract.

5. A method of improving wound healing in a human subject, comprising:

applying a composition comprising a salmon egg cellular extract having a protein content of from about 180-260 mg/ml to a wound of said subject under conditions such wound healing is improved, wherein said improvement is selected from the group consisting of faster healing, increased scar tissue reorganization, less visible scar tissue thickness, lower epidermal thickness, lower dermal thickness and combinations thereof.

6. The method of claim 5, wherein said composition is applied to a wound in the skin of said subject.

7. The method of claim 5, wherein said composition is provided in a cream, gel, emulsion, ointment, spray, powder or lotion.

8. The method of claim 5, wherein said salmon egg extract is a cytoplasmic extract.