Drug delivery device and methods having a retaining member

• US 10,478,603 B2
• Filed: 09/13/2017
• Issued: 11/19/2019
• Est. Priority Date: 07/25/2014
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Clay, Danielle L., Snyder, Lloyd, Soucia, Jeffrey A., Merves, Michael, Belton, Antonio, Corrigan, Sean, Grider, Keith, Lau, Michael Honsing, Leatzow, Derek
• Primary Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US15/703,512
• Publication Number:
  US 20180001072A1
• Time in Patent Office: 797 Days
• CPC Class Codes: A61M 2205/32 with radio-opaque indicia
• CPC Class Codes: A61M 2205/584 having a color code
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31576 Constructional features or modes of drive mechanisms for piston rods

Abstract

Various embodiments of a device, a kit and method for delivering a drug depot are disclosed. The device comprises a housing including a lower body, an upper body, a ring member; and a drug cartridge. The lower body defines a lower body channel. The upper body defines an upper body channel. The drug cartridge defines a depot channel. The ring member is disposed extending upward from an annular step surface of the lower body toward a housing upper end. The ring member includes indicia indicating a characteristic of one or more drug depots in the drug cartridge. A plunger has a push rod for expelling the drug depot through the cannula to a site in the patient. A kit comprises the above components. A method includes assembling the components including selecting a ring member having indicia corresponding to one or more drug depots in the drug cartridge.

Claims

1. A drug delivery device comprising:

a housing comprising a cavity; and

a drug cartridge removably positioned in the cavity, the drug cartridge comprising a first plate having a channel with a drug pellet positioned therein, the drug cartridge comprising a second plate that is coupled to the first plate, the second plate comprising a first end including a first cantilever arm and an opposite second end including a cantilever arm, the cantilever arms being configured to effect an elastic occlusion of the channel,

wherein the second plate comprises an interior portion, a first gap between the interior portion and the first cantilever arm and a second gap between the interior portion and the second cantilever arm,

wherein the interior portion comprises spaced apart bosses that are positioned within apertures of the first plate.

2. A drug delivery device as recited in claim 1, wherein a force is required to deflect the cantilever arms so as to permit passage of the drug pellet through the channel.

3. A drug delivery device as recited in claim 1, wherein the cantilever arms are each configured to occlude the channel at an occluding position such that the drug pellet cannot pass through the channel at the occluding positions without force, greater than that of gravity, applied to the drug pellet sufficient to deflect one of the cantilever arms an amount permitting passage of the drug pellet past one of the cantilever arms.

4. A drug delivery device as recited in claim 1, wherein the gaps are spaced apart from one another.

5. A drug delivery device as recited in claim 1, wherein the first cantilever arm comprises a first planar surface and a first protrusion that extends outwardly from the first planar surface and the second cantilever arm comprises a second planar surface and a second protrusion that extends outwardly from the second planar surface, the protrusions being configured to at least partially occlude the channel at proximal and distal positions of the channel to prevent passage of the drug pellet.

6. A drug delivery device as recited in claim 5, further comprising a push rod configured to apply a force to at least one of the cantilever arms to allow passage of the drug pellet through the channel.

7. A drug delivery device as recited in claim 1, wherein the first plate comprises a pair of notches and the second plate comprises hook engaging protrusions that are positioned within the notches to couple the second plate to the first plate.

8. A drug delivery device as recited in claim 1, wherein the channel has a depth at least equal to a diameter of the drug pellet.

9. A drug delivery device as recited in claim 1, wherein the first plate comprises ridges that mate with grooves of the housing to align the drug cartridge with the housing.

10. A drug delivery device as recited in claim 1, wherein the drug cartridge comprises a clear material and the housing comprising a viewing aperture such that the drug pellet is viewable through the viewing aperture.

11. A drug delivery device as recited in claim 1, wherein the housing comprises an opening that extends through a distal end of the housing, the opening being in communication with the channel.

12. A drug delivery device comprising:

a housing comprising a cavity; and

a drug cartridge removably positioned in the cavity, the drug cartridge comprising a first plate having a channel with a drug pellet positioned therein, the drug cartridge comprising a second plate that is coupled to the first plate, the second plate comprising a first end including a first cantilever arm and an opposite second end including a cantilever arm, the cantilever arms being configured to effect an elastic occlusion of the channel,

wherein the first plate comprises a pair of notches and the second plate comprises hook engaging protrusions that are positioned within the notches to couple the second plate to the first plate.

13. A drug delivery device as recited in claim 12, wherein a force is required to deflect the cantilever arms so as to permit passage of the drug pellet through the channel.

14. A drug delivery device as recited in claim 12, wherein the cantilever arms are each configured to occlude the channel at an occluding position such that the drug pellet cannot pass through the channel at the occluding positions without force, greater than that of gravity, applied to the drug pellet sufficient to deflect one of the cantilever arms an amount permitting passage of the drug pellet past one of the cantilever arms.

15. A drug delivery device as recited in claim 12, wherein the second plate comprises an interior portion, a first gap between the interior portion and the first cantilever arm and a second gap between the interior portion and the second cantilever arm.

16. A drug delivery device as recited in claim 15, wherein the gaps are spaced apart from one another.

17. A drug delivery device as recited in claim 12, wherein the first cantilever arm comprises a first planar surface and a first protrusion that extends outwardly from the first planar surface and the second cantilever arm comprises a second planar surface and a second protrusion that extends outwardly from the second planar surface, the protrusions being configured to at least partially occlude the channel at proximal and distal positions of the channel to prevent passage of the drug pellet.

18. A drug delivery device as recited in claim 17, further comprising a push rod configured to apply a force to at least one of the cantilever arms to allow passage of the drug pellet through the channel.

19. A drug delivery device as recited in claim 12, wherein the channel has a depth at least equal to a diameter of the drug pellet.

20. A drug delivery device as recited in claim 12, wherein the first plate comprises ridges that mate with grooves of the housing to align the drug cartridge with the housing.

21. A drug delivery device as recited in claim 12, wherein the drug cartridge comprises a clear material and the housing comprising a viewing aperture such that the drug pellet is viewable through the viewing aperture.

22. A drug delivery device as recited in claim 12, wherein the housing comprises an opening that extends through a distal end of the housing, the opening being in communication with the channel.

23. A drug delivery device comprising:

a housing comprising a cavity; and

a drug cartridge removably positioned in the cavity, the drug cartridge comprising a first plate having a channel with a drug pellet positioned therein, the drug cartridge comprising a second plate that is coupled to the first plate, the second plate comprising a first end including a first cantilever arm and an opposite second end including a cantilever arm, the cantilever arms being configured to effect an elastic occlusion of the channel,

wherein the first plate comprises ridges that mate with grooves of the housing to align the drug cartridge with the housing.

24. A drug delivery device as recited in claim 23, wherein a force is required to deflect the cantilever arms so as to permit passage of the drug pellet through the channel.

25. A drug delivery device as recited in claim 23, wherein the cantilever arms are each configured to occlude the channel at an occluding position such that the drug pellet cannot pass through the channel at the occluding positions without force, greater than that of gravity, applied to the drug pellet sufficient to deflect one of the cantilever arms an amount permitting passage of the drug pellet past one of the cantilever arms.

26. A drug delivery device as recited in claim 23, wherein the second plate comprises an interior portion, a first gap between the interior portion and the first cantilever arm and a second gap between the interior portion and the second cantilever arm.

27. A drug delivery device as recited in claim 26, wherein the gaps are spaced apart from one another.

28. A drug delivery device as recited in claim 23, wherein the first cantilever arm comprises a first planar surface and a first protrusion that extends outwardly from the first planar surface and the second cantilever arm comprises a second planar surface and a second protrusion that extends outwardly from the second planar surface, the protrusions being configured to at least partially occlude the channel at proximal and distal positions of the channel to prevent passage of the drug pellet.

29. A drug delivery device as recited in claim 28, further comprising a push rod configured to apply a force to at least one of the cantilever arms to allow passage of the drug pellet through the channel.

30. A drug delivery device as recited in claim 23, wherein the channel has a depth at least equal to a diameter of the drug pellet.

31. A drug delivery device as recited in claim 23, wherein the drug cartridge comprises a clear material and the housing comprising a viewing aperture such that the drug pellet is viewable through the viewing aperture.

32. A drug delivery device as recited in claim 23, wherein the housing comprises an opening that extends through a distal end of the housing, the opening being in communication with the channel.