Method for in-line control of the integrity of a filtering system

• US 10,478,765 B2
• Filed: 05/13/2015
• Issued: 11/19/2019
• Est. Priority Date: 05/15/2014
• Status: Active Grant

• Current Assignee: Roquette Freres
• Original Assignee: Roquette Freres
• Inventors: Segard, David
• Primary Examiner(s): Clemente, Robert
• Application Number:
  US15/305,376
• Publication Number:
  US 20170043290A1
• Time in Patent Office: 1,651 Days
• CPC Class Codes: B01D 2273/18 Testing of filters, filter elements, sealings
• CPC Class Codes: B01D 2279/65 for the sterilisation of air disinfection, sterilisation or deodorization of air A61L9/00
• CPC Class Codes: B01D 46/0086 Filter condition indicators
• CPC Class Codes: B01D 46/446 by pressure measuring

Abstract

A method for in-line control of the integrity of a filtering system implemented during an industrial process including the filtering of a gas through the filtering system, the filtering system including at least one filtering cartridge, the method including at least the following steps: —a measurement step (S1) which involves measuring a pressure difference ΔP representative of the pressure loss caused by the filtering system (F1; F2), —a testing step (S2, S3) which involves comparing the measurement (S1) with a predefined high threshold (Sh) and a predefined low threshold (Sb), in such a way as to consider the at least one filtering cartridge to be non-compliant when the pressure difference measured in the measurement step (S1) falls outside a range located between the high threshold (Sh) and the low threshold (Sb).

Claims

1. A method for in-line control of the integrity of a filtering system implemented in an industrial process involving the filtration of a gas through said filtering system, wherein the industrial process is an industrial process for which said filtration is a sterilizing filtration, said filtering system (F1;

F2) comprising at least one filtering cartridge, the method comprising at least the following steps;

a measuring step (S1) during which a pressure difference Δ

P, representative of the pressure loss generated by the filtering system (F1;

F2), is measured,

a testing step (S2, S3) during which said measurement (S1) is compared to a predetermined upper threshold (Sh) and a predetermined lower threshold (Sb), in such a way as to consider said at least one filtering cartridge to be non-compliant when the pressure difference measured in the measuring step (S1) falls outside a range located between said upper threshold (Sh) and said lower threshold (Sb)

said method comprising a preliminary step (S01) for measuring the pressure difference Δ

P0 representative of the pressure loss generated by the filtering system when said at least one filtering cartridge is new, and a calibration step during which a calculation is notably used to determine said upper threshold (Sh) and the lower threshold (Sb) depending on said pressure difference Δ

P0 measured,

wherein the measurement of the pressure difference made during the measuring step (S1) is performed by means of a pressure difference measuring device having sensitivity of 5% or less of the value Δ

P0 representative of the pressure loss generated by the filtering system when said at least one filtering cartridge is new,

Wherein Δ

P0 being the pressure loss generated by the filtering system when said at least one cartridge is new, and wherein the value of the lower threshold (Sb) is between 0.7*Δ

P0 and 0.95*Δ

P0 and wherein the value of the upper threshold (Sh) is between 1.3*Δ

P0 and 3*Δ

P0, and wherein the state of integrity of said at least cartridge in the sense that the filtered gas are considered sterile is implemented by monitoring only pressure difference Δ

P, representative of the pressure loss generated by the filtering system (F1;

F2).

2. The method as claimed in claim 1, wherein the value of the upper threshold (Sh) is between 1.4*Δ

P0 and 2*Δ

P0.

3. The method as claimed in claim 1, wherein the value of the upper threshold (Sh) is between 1.4*Δ

P0 and 2*Δ

P0.

4. The method as claimed in claim 1, wherein the value of the upper threshold (Sh) is between 1.4*Δ

P0 and 1.6Δ

P0.

5. The method as claimed in claim 1, Δ

P0 being the pressure loss generated by the filtering system when said at least one cartridge is new, and wherein the value of the lower threshold (Sb) is between 0.88*Δ

P0 and 0.92*Δ

P0.

6. The method as claimed in claim 1, wherein the measurement of the pressure difference made during the measuring step (S1) is performed by means of a pressure difference measuring device having sensitivity less or equal to 300 Pascals said device having a first pressure connection (C1) downstream from the filtering system and a second pressure connection (C2) upstream from the filtering system.

7. The method as claimed in claim 1, comprising the following steps, implemented by computer means:

a step of emitting a signal comprising a measurement relative to the pressure difference Δ

P measured during the measuring step (S1),

a step of recording said measured pressure difference value, in a computer file, at a time interval or in a continuous manner.

8. The method as claimed in claim 7, comprising a step of generating a warning signal (Ae;

Af) when said measured pressure difference falls outside said range between said upper threshold (Sh) and said lower threshold (Sb).

9. The method as claimed in claim 1, wherein the filtering system (F1;

F2) comprises a plurality of filtering cartridges, said pressure difference measured at measuring step (S1) being representative of the pressure loss generated by all the filtering cartridges.

10. The method as claimed in claim 7, wherein the measurement sensitivity between 50 Pascals and 200 Pascals.

11. The method as claimed in claim 1, wherein the measurement scale comprises a range between 75,000 Pascals and 200,000 Pascals.

12. The method as claimed in claim 1, wherein the industrial process is an industrial process providing normal gas flow rates to the filtering system greater than 100 Nm³/H.

13. The method as claimed in claim 1, wherein the industrial process is an industrial fermentation process and wherein the filtering system (F1;

F2) is used to treat the air supplying the fermentation reactor (R) or the tank of a material (G1) such as the glucose supplying the fermentation reactor (R).