Glucose multi-vital-sign system in an electronic medical records system

• US 10,485,431 B1
• Filed: 05/21/2018
• Issued: 11/26/2019
• Est. Priority Date: 05/21/2018
• Status: Active Grant

• Current Assignee: ARC Devices, Ltd.
• Original Assignee: Arc Devices (Ni) Limited
• Inventors: Khachaturian, Mark, Smith, Michael
• Primary Examiner(s): Roane, Aaron F
• Application Number:
  US15/985,672
• Publication Number:
  US 20190350469A1
• Time in Patent Office: 554 Days
• Field of Search: 600301
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0077 Devices for viewing the surface of the body, e.g. camera, magnifying lens
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/02241 of small dimensions, e.g. adapted to fingers
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: G06T 2210/22 Cropping
• CPC Class Codes: G06T 3/40 Scaling of whole images or parts thereof, e.g. expanding or contracting
• CPC Class Codes: G16H 10/60 : for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 30/40 : for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A device measures blood glucose levels, temperature, heart rate, heart rate variability, respiration, SpO2, blood flow, blood pressure, total hemoglobin (SpHb), PVi, methemoglobin (SpMet), acoustic respiration rate (RRa), carboxyhemoglobin (SpCO), oxygen reserve index (ORi), oxygen content (SpOC) and/or EEG of a human.

Claims

1. An apparatus to determine a plurality of vital signs, the apparatus comprising:

a microprocessor;

a wireless communication subsystem that is operably coupled to the microprocessor and that is configured to transmit a representation of the plurality of vital signs, the plurality of vital signs including a temperature, an amount of glucose and an amount of oxygen;

a digital infrared sensor that is operably coupled to the microprocessor with no analog-to-digital converter being operably coupled between the digital infrared sensor and the microprocessor, the digital infrared sensor having only digital readout ports, the digital infrared sensor having no analog sensor readout ports, the digital infrared sensor including a Faraday cage surrounding a single thermopile sensor and a central processing unit control block that digitizes output of the single thermopile sensor; and

a first housing that contains the microprocessor, the wireless communication subsystem and the digital infrared sensor;

a glucose subsystem that includes a second housing, the housing including a source-detector assembly having a first side and a second side;

the first side having two transmitters of electromagnetic radiation in a 375-415 nm frequency range and a 920-960 nm frequency range and a first photodiode receiver of electromagnetic radiation in a 350-1100 nm range to measure an amount of electromagnetic radiation that is reflected by a subject that is positioned between the first side and the second side, wherein the microprocessor is configured to receive from the digital readout ports a digital signal that is representative of an infrared signal of the temperature that is detected by the digital infrared sensor and the microprocessor is configured to determine the plurality of vital signs from data from the first photodiode receiver and from the digital signal that is representative of the infrared signal in reference to a plurality of tables that are stored in a memory that correlate the temperature to the plurality of vital signs,

a finger occlusion cuff having a third housing;

a central longitudinal axis of the third housing of the finger occlusion cuff is not coaxial with a central longitudinal axis of the second housing of the glucose subsystem, wherein the second housing and the third housing are aligned so that a finger can be inserted through the finger occlusion cuff and into the glucose subsystem,

wherein the second housing of the glucose subsystem is mounted to the first housing,

wherein the third housing of the finger occlusion cuff is mounted to the first housing,

wherein the microprocessor is configured to determine an indication of the amount of glucose in the subject calculated from a ratio of electromagnetic radiation received in the 375-415 nm frequency range in comparison to electromagnetic radiation received in the 920-960 nm frequency range,

wherein the microprocessor is configured to determine an indication of the amount of oxygen in the subject calculated from a ratio of electromagnetic radiation received in a 640-680 nm frequency range in comparison to electromagnetic radiation received in a 920-960 nm frequency range,

wherein a connection is established by the wireless communication subsystem to an external device and the plurality of vital signs are pushed from the apparatus through the wireless communication subsystem, wherein the connection further comprises an authenticated communication channel.

2. The apparatus of claim 1, wherein the first photodiode receiver of electromagnetic radiation in the first side receives the electromagnetic radiation in the 375-415 nm frequency range.

3. The apparatus of claim 1 further comprising a camera that is operably coupled to the microprocessor and configured to provide a plurality of images to the microprocessor, the microprocessor further comprising:

a cropper module that is configured to receive the plurality of images and that is configured to crop each of the plurality of images to exclude a border area of the images, generating a plurality of cropped images,

a pixel-examination-module configured to examine pixel-values of the plurality of cropped images,

a temporal-variation module to determine a temporal variation of the pixel-values between the plurality of cropped images being below a particular threshold,

a signal processing module configured to amplify the temporal variation resulting in an amplified-temporal-variation, and

a visualizer to visualize a pattern of flow of blood in the amplified-temporal-variation in the plurality of images.

4. The apparatus of claim 1 wherein electromagnetic radiation in the 375-415 nm frequency range is received by the first photodiode receiver of electromagnetic radiation.

5. The apparatus of claim 1 further comprising:

a first circuit board including the microprocessor and a first digital interface operably coupled to the microprocessor; and

the first housing that contains the first circuit board and that does not contain the camera.

6. The apparatus of claim 1 wherein the wireless communication subsystem transmits via a short distance wireless communication path.

7. The apparatus of claim 5 further comprising:

a second circuit board in a smartphone, the smartphone having a fourth housing and the camera; and

a second digital interface, the second digital interface being operably coupled to the first digital interface and the second digital interface being operably coupled to the digital infrared sensor.