Formulation and method for treatment of non-acne scars

• US 10,485,755 B1
• Filed: 01/08/2019
• Issued: 11/26/2019
• Est. Priority Date: 02/05/2018
• Status: Active Grant

• Current Assignee: Wade Cheng
• Original Assignee: Wade Cheng
• Inventors: Cheng, Wade
• Primary Examiner(s): Soroush, Ali
• Application Number:
  US16/242,970
• Time in Patent Office: 322 Days
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 2210/04 Skin
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 37/0076 Tattooing apparatus apparatus for marking animals A01K11/00; vaccine applicators having needles or other puncturing means A61B17/205
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A chemical formula and method for treatment of non-acne skin scar tissue, in particular, hypertrophic and keloid scars. The chemical formula can comprise a topical chemical solution comprising alcohol, 1,3-dihydroxybenzene, alpha-hydroxy acids, and beta-hydroxy acids. This may be coated on the skin directly, or alternatively the surface of the skin scar can optionally be prepared by puncturing it with a plurality of small holes or micropunctures applied by microneedle or dry needle techniques, and the chemical solution can be applied by a brush or other method. Often a plurality of coatings, with intermediate air drying, may be required to deposit a sufficient amount of chemical during a treatment session. The scar area is then kept dry to help allow the chemical to penetrate, and the scar allowed to heal for about two weeks before any subsequent treatment. Experimental results showing the excellent efficacy of the formula and method are presented.

Claims

1. A method of treatment of non-acne skin scar tissue, said method comprising:

over a plurality of scar reduction sessions, applying a scar reduction topical chemical solution to said skin scar tissue by the steps of;

a) applying an alcohol-based scar reduction topical chemical solution to said skin scar tissue;

b) allowing at least the alcohol in said alcohol-based topical scar reduction chemical solution to evaporate, thus depositing chemicals in said scar reduction topical chemical solution on at least the surface of said skin scar tissue;

wherein said skin scar tissue comprises any of non-acne hypertrophic scars raised above a level of the skin surrounding said scar, surgical scars, and keloid scars that grow outside of an area of an original wound;

c) repeating steps a-b so as to produce a plurality of said deposits on at least said surface of said skin scar tissue;

wherein said scar reduction topical chemical solution comprises;

10 to 90% alcohol,

5 to 25% 1,3-dihydroxybenzene,

5 to 25% alpha-hydroxy acids, and

5 to 25% beta-hydroxy acids;

wherein said method promotes the distribution of scar tissue protein fibers in an orderly orientation more closely resembling normal skin proteins.

2. The method of claim 1, wherein said alpha-hydroxy acids comprise alpha-hydroxy acids selected from the group consisting of lactic acid, glycolic acid, and citric acid.

3. The method of claim 1, wherein said beta-hydroxy acids comprise beta-hydroxy acids selected from the group consisting of salicylic acid and 3-Hyrdoxybutanoic acid.

4. The method of claim 1, further using any of a microneedle device, or a dry needle device to prepare said skin scar tissue either before or during application of said scar reduction topical chemical solution, said microneedle device or dry needle device is configured to penetrate at least 0.5 millimeters into said skin scar tissue, thus producing a plurality of micropunctures configured to allow at least some of said scar reduction topical chemical solution to be transported below a surface of said skin scar tissue.

5. The method of claim 1, further using a dry needle device to prepare said skin scar tissue either before or during application of said scar reduction topical chemical solution, said dry needle device configured to penetrate at least 0.5 millimeters into said skin scar tissue, thus producing a plurality of micropunctures configured to allow at least some of said scar reduction topical chemical solution to be transported below a surface of said skin scar tissue;

wherein said dry needle device comprises a micropigmentation needle operated with a cosmetic tattoo machine.

6. The method of claim 1, further allowing said scar tissue to heal for at least 15 days before repeating steps a-c.

11. The method of claim 1, wherein said non-acne skin scar tissue comprises surgical scars and keloid scars that grow outside of an area of an original wound.

14. The method of claim 1, wherein said scar reduction topical chemical solution further comprises:

10 to 59% alcohol,

13 to 25% 1,3-dihydroxybenzene,

13 to 25% alpha-hydroxy acids, and

8 to 25% beta-hydroxy acids.

7. A method of treatment of non-acne skin scar tissue, said method comprising:

over a plurality of scar reduction sessions, applying a scar reduction topical chemical solution to said skin scar tissue by the steps of;

using a dry needle device to produce a plurality of micropunctures through a surface of said skin scar tissue, said dry needle device configured to penetrate at least 0.5 millimeters past said surface of said skin scar tissue;

wherein said skin scar tissue comprises any of non-acne hypertrophic scars raised above a level of skin surrounding said skin scar tissue, surgical scars, and keloid scars that grow outside of an area of an original wound;

a) applying an alcohol-based scar reduction topical chemical solution to said skin scar tissue, wherein said plurality of micropunctures are configured to allow at least some of said scar reduction topical chemical solution to be transported below said surface of said skin scar tissue;

b) allowing at least the alcohol in said alcohol-based scar reduction topical chemical solution to evaporate, thus depositing chemicals in said scar reduction topical chemical solution on at least a surface of said skin scar tissue;

c) repeating steps a-b so as to produce a plurality of said deposits on at least said surface of said skin scar tissue;

wherein said scar reduction topical chemical solution comprises;

10 to 90% alcohol,

5 to 25% 1,3-dihydroxybenzene,

5 to 25% alpha-hydroxy acids, and

5 to 25% beta-hydroxy acids;

wherein said method promotes the distribution of scar tissue protein fibers in an orderly orientation more closely resembling normal skin proteins.

8. The method of claim 7, wherein said alpha-hydroxy acids comprise at least one alpha-hydroxy acid selected from the group consisting of lactic acid, glycolic acid, and citric acid.

9. The method of claim 7, wherein said beta-hydroxy acids comprise at least one beta-hydroxy acid selected from the group consisting of salicylic acid and 3-Hyrdoxybutanoic acid.

10. The method of claim 7, further allowing said skin scar tissue to heal for at least 15 days before repeating steps a-c.

12. The method of claim 7, wherein said non-acne skin scar tissue comprises surgical scars and keloid scars that grow outside of an area of an original wound.

13. The method of claim 7, wherein said dry needle device comprises a micropigmentation needle operated with a cosmetic tattoo machine.

15. The method of claim 7, wherein said scar reduction topical chemical solution further comprises:

10 to 59% alcohol,

13 to 25% 1,3-dihydroxybenzene,

13 to 25% alpha-hydroxy acids, and

8 to 25% beta-hydroxy acids.