Dual prophylactic and abortive electrical stimulation

• US 10,485,970 B2
• Filed: 10/12/2017
• Issued: 11/26/2019
• Est. Priority Date: 04/29/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gerber, Martin T., Goetz, Steven M., Poletto, Christopher
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Piateski, Erin M
• Application Number:
  US15/782,272
• Publication Number:
  US 20180036530A1
• Time in Patent Office: 775 Days
• Field of Search: 607 46
• CPC Class Codes: A61N 1/36 for stimulation
• CPC Class Codes: A61N 1/36057 adapted for stimulating afferent nerves
• CPC Class Codes: A61N 1/36075 Headache or migraine
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36132 using patient feedback

Abstract

Prophylactic stimulation and abortive electrical stimulation are delivered to a cranial nerve, including, e.g. an occipital or trigeminal nerve to treat symptoms of various conditions, including, e.g. occipital neuralgia or migraines.

Claims

1. A system comprising:

an electrical stimulation generator;

a plurality of electrodes;

a memory that stores, for each electrode of the plurality of electrodes, a range of stimulation thresholds associated with the respective electrode; and

a processor configured to select a combination of electrodes of the plurality of electrodes, determine the ranges of stimulation thresholds associated with the electrodes of the combination in the memory, and control the electrical stimulation generator to deliver prophylactic electrical stimulation and abortive electrical stimulation to a patient via the combination of electrodes and within the ranges of stimulation thresholds associated with the electrodes of the combination in the memory,

wherein the prophylactic stimulation is configured to inhibit onset of a symptom of a patient condition, and wherein the abortive stimulation is configured to reduce an effect of a symptom of the patient condition.

2. The system of claim 1, wherein each range of stimulation thresholds is bounded by a low stimulation threshold and a high stimulation threshold.

3. The system of claim 2, wherein the low stimulation threshold is a perception threshold or a paresthesia threshold for the patient.

4. The system of claim 2, wherein the high stimulation threshold is a discomfort threshold, a muscle recruitment threshold, or a pain threshold for the patient.

5. The system of claim 1, wherein the range of stimulation thresholds comprises a first range of stimulation thresholds associated with an abortive stimulation mode, and wherein the memory stores, for each electrode of the plurality of electrodes, a second range of stimulation thresholds associated with the respective electrode, the second range of stimulation thresholds being associated with a prophylactic stimulation mode, the processor being configured to:

control the electrical stimulation generator to deliver the abortive electrical stimulation to the patient via the combination of electrodes and within the first ranges of stimulation thresholds associated with the electrodes of the combination in the memory, and

control the electrical stimulation generator to deliver the prophylactic electrical stimulation to the patient via the combination of electrodes and within the second ranges of stimulation thresholds associated with the electrodes of the combination in the memory.

6. The system of claim 5, wherein the processor is configured to control the electrical stimulation generator to deliver the abortive stimulation at least by reducing a stimulation intensity of the prophylactic stimulation from within the first ranges of stimulation intensity thresholds to within the second ranges of stimulation intensity thresholds.

7. The system of claim 5, wherein the processor is configured to control the electrical stimulation generator to deliver the abortive electrical stimulation by at least controlling the electrical stimulation generator to deliver a first abortive stimulation after onset of a symptom of a chronic condition is anticipated and deliver a second abortive stimulation while the symptom of the chronic condition is occurring, and wherein the processor is configured to control the electrical stimulation generator to deliver the second abortive stimulation after an intensity level of the symptom has increased above a level during the onset of the symptom.

8. The system of claim 5, wherein the processor is configured to receive an indication of anticipating onset of a symptom of a chronic condition, and wherein the processor is configured to control the electrical stimulation generator to deliver the abortive stimulation in response to receiving the indication of anticipating the onset of the symptom of the chronic condition.

9. The system of claim 5, wherein the first ranges of stimulation intensity thresholds are each determined based on patient perception in the absence of any symptoms of a chronic condition, and the second ranges of stimulation intensity thresholds are each determined based on patient perception while a symptom of the chronic condition is occurring.

10. The system of claim 5, wherein, for each electrode, the first range of stimulation thresholds and the second range of stimulation thresholds are mutually exclusive.

11. The system of claim 5, wherein, for each electrode, the first range of stimulation thresholds and the second range of stimulation thresholds partially overlap.

12. The system of claim 1, further comprising an external programmer comprising the processor.

13. The system of claim 1, further comprising a medical device comprising a housing, wherein the electrical stimulation generator and the processor reside within the housing.

14. A method comprising:

selecting, by a processor, a combination of electrodes from a plurality of electrodes;

determining, by the processor and for each electrode of the combination of electrodes, a range of stimulation thresholds associated with the respective electrode in a memory; and

controlling, by the processor, an electrical stimulation generator to deliver prophylactic electrical stimulation and abortive electrical stimulation to a patient via the combination of electrodes and within the ranges of stimulation thresholds associated with the electrodes of the combination in the memory,

wherein the prophylactic stimulation is configured to inhibit onset of a symptom of a patient condition, and wherein the abortive stimulation is configured to reduce an effect of a symptom of the patient condition.

15. The method of claim 14, wherein each range of stimulation thresholds is bounded by a low stimulation threshold and a high stimulation threshold, the method further comprising, for at least one electrode of the plurality of electrodes:

determining the low stimulation threshold based on patient perception in the absence of any symptoms of a chronic condition, wherein determining the low stimulation threshold comprises controlling the electrical stimulation generator to deliver a stimulation intensity via the at least one electrode and ramp the stimulation intensity from a baseline level of intensity up to a level in which a patient indicates the low stimulation threshold has been reached; and

determining the high stimulation threshold based on patient perception while a symptom of the chronic condition is occurring, wherein determining the high stimulation threshold comprises controlling the electrical stimulation generator to deliver a stimulation intensity via the at least one electrode, and ramp the stimulation intensity from the baseline level of intensity up to a level in which the patient indicates the high stimulation threshold has been reached; and

storing the range of stimulation thresholds in the memory.

16. The method of claim 15, wherein the low stimulation threshold comprises a perception threshold or a paresthesia threshold.

17. The method of claim 15, wherein the high stimulation threshold comprises a discomfort threshold, a muscle recruitment threshold, or a pain threshold.

18. The method of claim 14, wherein determining the range of stimulation thresholds for each electrode of the combination comprises:

determining, for the respective electrode, a first range of stimulation thresholds associated with an abortive stimulation mode; and

determining, for the respective electrode, a second range of stimulation thresholds associated with a prophylactic stimulation mode, and

wherein controlling the electrical stimulation generator to deliver the prophylactic electrical stimulation and the abortive electrical stimulation to the patient comprises;

controlling the electrical stimulation generator to deliver the abortive electrical stimulation to the patient via the combination of electrodes and within the first ranges of stimulation thresholds associated with the electrodes of the combination in the memory; and

controlling the electrical stimulation generator to deliver the prophylactic electrical stimulation to the patient via the combination of electrodes and within the second ranges of stimulation thresholds associated with the electrodes of the combination in the memory.

19. The method of claim 18, wherein, for each electrode, the first range of stimulation thresholds and the second range of stimulation thresholds are mutually exclusive.

20. The method of claim 18, wherein, for each electrode, the first range of stimulation thresholds and the second range of stimulation thresholds partially overlap.

21. The method of claim 14, wherein controlling the electrical stimulation generator to deliver the prophylactic electrical stimulation and the abortive electrical stimulation to the patient comprises:

controlling the electrical stimulation generator to deliver a first abortive stimulation after onset of a symptom of a chronic condition is anticipated; and

controlling the electrical stimulation generator to deliver a second abortive stimulation while the symptom of the chronic condition is occurring, and after an intensity level of the symptom has increased above a level during the onset of the symptom.

22. The method of claim 19, further comprising receiving, by the processor, an indication of anticipating onset of a symptom of a chronic condition, wherein controlling the electrical stimulation generator to deliver the prophylactic electrical stimulation and the abortive electrical stimulation to the patient comprises controlling the electrical stimulation generator to deliver the abortive stimulation in response to receiving the indication of anticipating the onset of the symptom of the chronic condition.

23. A computer-readable storage medium comprising instructions that, when executed by a programmable processor, cause the processor to:

select a combination of electrodes from a plurality of electrodes;

determine, for each electrode of the combination of electrodes, a range of stimulation thresholds associated with the respective electrode in a memory; and

control an electrical stimulation generator to deliver prophylactic electrical stimulation and abortive electrical stimulation to a patient via the combination of electrodes and within the ranges of stimulation thresholds associated with the electrodes of the combination in the memory,

wherein the prophylactic stimulation is configured to inhibit onset of a symptom of a patient condition, and wherein the abortive stimulation is configured to reduce an effect of a symptom of the patient condition.

24. The computer-readable storage medium of claim 23, wherein the range of stimulation thresholds comprises a first range of stimulation thresholds associated with an abortive stimulation mode, and wherein the memory stores, for each electrode of the plurality of electrodes, a second range of stimulation thresholds associated with the respective electrode, the second range of stimulation thresholds being associated with a prophylactic stimulation mode, the computer-readable storage medium further comprising instructions that, when executed by the processor, cause the processor to:

control the electrical stimulation generator to deliver the abortive electrical stimulation to the patient via the combination of electrodes and within the first ranges of stimulation thresholds associated with the electrodes of the combination in the memory, and

control the electrical stimulation generator to deliver the prophylactic electrical stimulation to the patient via the combination of electrodes and within the second ranges of stimulation thresholds associated with the electrodes of the combination in the memory.