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Antisense nucleic acids

DC CAFC
  • US 10,487,106 B2
  • Filed: 03/29/2019
  • Issued: 11/26/2019
  • Est. Priority Date: 09/01/2010
  • Status: Active Grant
First Claim
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1. A phosphorodiamidate morpholino oligomer (PMO) consisting of a 25-mer antisense oligomer that is 100% complementary, according to Watson-Crick base pairing, to the 36th to the 60th nucleotides from the 5′

  • end of the 53rd exon in a human dystrophin pre-mRNA, wherein the 53rd exon in said human dystrophin pre-mRNA consists of a nucleotide sequence corresponding to SEQ ID NO;

    1, wherein each phosphorodiamidate morpholino monomer of said PMO has the formula;

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