Methods and apparatus for detecting an entity in a bodily sample
First Claim
1. Apparatus comprising:
- a microscope system configured to acquire one or more microscope images of a bodily sample selected from the group consisting of;
a blood sample, a diluted blood sample, a sample comprising predominantly red blood cells, and a diluted sample comprising predominantly red blood cells;
an output device; and
at least one computer processor configured to;
identify, in the one or more images, at least one element as being a pathogen candidate,extract, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate,extract, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample, the sample-informative feature being selected from the group consisting of;
an indication of a presence of Howell Jolly bodies within the bodily sample, a concentration of platelets within the bodily sample, a relationship between a number of reticulocytes associated with candidates and a number of mature red blood cells associated with candidates, and a concentration of reticulocyte bodies within the bodily sample;
determining a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature, andgenerate an output upon the output device, in response thereto.
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Abstract
Apparatus and methods are described including a microscope system (11) configured to acquire one or more microscope images of a bodily sample, an output device (34), and at least one computer processor (28). The computer processor identifies, in the one or more images, at least one element as being a pathogen candidate, and extracts, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate. The compute processor extracts, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample. The computer processor classifies a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.
327 Citations
27 Claims
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1. Apparatus comprising:
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a microscope system configured to acquire one or more microscope images of a bodily sample selected from the group consisting of;
a blood sample, a diluted blood sample, a sample comprising predominantly red blood cells, and a diluted sample comprising predominantly red blood cells;an output device; and at least one computer processor configured to; identify, in the one or more images, at least one element as being a pathogen candidate, extract, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate, extract, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample, the sample-informative feature being selected from the group consisting of;
an indication of a presence of Howell Jolly bodies within the bodily sample, a concentration of platelets within the bodily sample, a relationship between a number of reticulocytes associated with candidates and a number of mature red blood cells associated with candidates, and a concentration of reticulocyte bodies within the bodily sample;determining a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature, and generate an output upon the output device, in response thereto. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method comprising:
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acquiring one or more microscope images of a bodily sample, using a microscope, the bodily sample being selected from the group consisting of;
a blood sample, a diluted blood sample, a sample comprising predominantly red blood cells, and a diluted sample comprising predominantly red blood cells;using at least one computer processor; in the one or more images, identifying at least one element as being a pathogen candidate; extracting, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate; extracting, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample, the sample-informative feature being selected from the group consisting of;
an indication of a presence of Howell Jolly bodies within the bodily sample, a concentration of platelets within the bodily sample, a relationship between a number of reticulocytes associated with candidates and a number of mature red blood cells associated with candidates, and a concentration of reticulocyte bodies within the bodily sample;determining a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature; and generating an output, in response thereto. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A computer software product, for use with a bodily sample, an output device, and a microscope system configured to acquire one or more microscope images of a bodily sample selected from the group consisting of:
- a blood sample, a diluted blood sample, a sample comprising predominantly red blood cells, and a diluted sample comprising predominantly red blood cells, the computer software product comprising a non-transitory computer-readable medium in which program instructions are stored, which instructions, when read by a computer cause the computer to perform the steps of;
in the one or more images, identifying at least one element as being a pathogen candidate;
extracting, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate;
extracting, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample the sample-informative feature being selected from the group consisting of;
an indication of a presence of Howell Jolly bodies within the bodily sample, a concentration of platelets within the bodily sample, a relationship between a number of reticulocytes associated with candidates and a number of mature red blood cells associated with candidates, and a concentration of reticulocyte bodies within the bodily sample;
determining a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature; and
generating an output upon the output device, in response thereto.
- a blood sample, a diluted blood sample, a sample comprising predominantly red blood cells, and a diluted sample comprising predominantly red blood cells, the computer software product comprising a non-transitory computer-readable medium in which program instructions are stored, which instructions, when read by a computer cause the computer to perform the steps of;
Specification