Method and system for image processing to determine blood flow

• US 10,492,866 B2
• Filed: 03/29/2017
• Issued: 12/03/2019
• Est. Priority Date: 08/12/2010
• Status: Active Grant

• Current Assignee: Heartflow Inc.
• Original Assignee: Heartflow Inc.
• Inventors: Taylor, Charles A.
• Primary Examiner(s): Goradia, Shefali D
• Application Number:
  US15/473,227
• Publication Number:
  US 20170202621A1
• Time in Patent Office: 979 Days
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Abstract

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.

Claims

1. A processing apparatus for processing cardiac image data of a living being, the processing apparatus executing a method comprising:

determining a plurality of fractional flow reserve values indicative of the fractional flow reserve of coronary arteries of the living being, the fractional flow reserve values corresponding to blood pressure values;

determining a plurality of myocardial perfusion values indicative of the myocardial perfusion of portions of the myocardium of the living being;

determining associations between the coronary arteries and the portions of the myocardium of the living being, wherein the associations define which of the portions of the myocardium are fed by which of the coronary arteries;

determining correspondences between the blood pressure values and the myocardial perfusion values based on the blood pressure values, the myocardial perfusion values, and the associations between the coronary arteries and portions of the myocardium; and

displaying indications indicative of the determined correspondences at one or more respective locations of the coronary arteries and/or of the portions of the myocardium.

2. The processing apparatus as defined in claim 1, wherein determining a plurality of fractional flow reserve values further comprises determining the plurality of fractional flow reserve values based on a three-dimensional geometry of the coronary artery tree.

3. The processing apparatus as defined in claim 2, wherein the processing apparatus executes a method further comprising determining a cardiac model, wherein the cardiac model models different portions of the myocardium fed by different coronary arteries.

4. The processing apparatus as defined in claim 1, wherein the processing apparatus executes a method further comprising:

displaying indications indicative of the determined correspondences at respective locations of the coronary arteries and/or of the portions of the myocardium.

5. The processing apparatus as defined in claim 1, wherein determining a plurality of fractional flow reserve values further comprises determining the plurality of fractional flow reserve values based on a first image of a heart of the living being generated by a first imaging type and wherein a myocardial perfusion determining unit, that determines the plurality of myocardial perfusion values, is adapted to determine the plurality of myocardial perfusion values based on a second image of the heart of the living being generated by a second imaging type, the second imaging type being different from the first imaging type.

6. A system for processing images of a heart of a living being, the system comprising:

a data storage device storing instructions for processing images of a heart of a living being; and

a processor configured to execute the instructions to perform a method comprising;

generating a first image of the heart, the first image indicative of the fractional flow reserve of coronary arteries of the living being, and generating a second image of the heart, the second image indicative of the myocardial perfusion of portions of the myocardium of the living being, the fractional flow reserve values corresponding to blood pressure values, and the myocardial perfusion of portions of the myocardium corresponding to myocardial perfusion values;

providing associations between the coronary arteries and the portions of the myocardium, wherein the associations define which of the portions of the myocardium are fed by which of the coronary arteries;

determining correspondences between the blood pressure values and myocardial perfusion values based on the blood pressure values, the myocardial perfusion values, and the associations between the coronary arteries and portions of the myocardium, wherein the plurality of blood pressure values are provided by determining blood pressure values based on the first image, and the plurality of myocardial perfusion values are provided by determining myocardial perfusion values based on the second image; and

displaying indications indicative of the determined correspondences at one or more respective locations of the coronary arteries and/or of the portions of the myocardium.

7. A processing method for processing cardiac imaging data of a living being, the processing method comprising:

determining a plurality of fractional flow reserve values indicative of the fractional flow reserve of coronary arteries of the living being, the fractional flow reserve values corresponding to blood pressure values;

determining a plurality of myocardial perfusion values indicative of the myocardial perfusion of portions of the myocardium of the living being;

determining associations between the coronary arteries and the portions of the myocardium of the living being, wherein the associations define which of the portions of the myocardium are fed by which of the coronary arteries;

determining correspondences between the blood pressure values and the myocardial perfusion values based on the blood pressure values, the myocardial perfusion values, and the associations between the coronary arteries and portions of the myocardium; and

displaying indications indicative of the determined correspondences at one or more respective locations of the coronary arteries and/or of the portions of the myocardium.

8. An non-transitory computer-readable medium comprising instructions for imaging a heart of a living being, the instructions configured to execute a method comprising:

generating a first image of the heart, the first image indicative of the fractional flow reserve of coronary arteries of the living being and generating a second image of the heart, the second image indicative of the myocardial perfusion of portions of the myocardium of the living being, the fractional flow reserve values corresponding to blood pressure values, the myocardial perfusion of portions of the myocardium corresponding to myocardial perfusion values;

providing associations between the coronary arteries and the portions of the myocardium, wherein the associations define which of the portions of the myocardium are fed by which of the coronary arteries;

determining correspondences between the blood pressure values and myocardial perfusion values based on the blood pressure values, the myocardial perfusion values, and the associations between the coronary arteries and portions of the myocardium, wherein the plurality of blood pressure values are provided by determining blood pressure values based on the first image and the plurality of myocardial perfusion values are provided by determining myocardial perfusion values based on the second image; and

displaying indications indicative of the determined correspondences at one or more respective locations of the coronary arteries and/or of the portions of the myocardium.