Mechanical actuator system and method of actuation of a diagnostic device therewith

• US 10,493,453 B2
• Filed: 03/08/2017
• Issued: 12/03/2019
• Est. Priority Date: 03/08/2016
• Status: Active Grant

• Current Assignee: Creganna Unlimited Company (TE Connectivity Limited)
• Original Assignee: David W Wright
• Inventors: Wright, David W.
• Primary Examiner(s): Gordon, Brian R
• Application Number:
  US15/453,606
• Publication Number:
  US 20170259268A1
• Time in Patent Office: 1,000 Days
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0867 Multiple inlets and one sample wells, e.g. mixing, dilution
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0683 mechanically breaking a wall or membrane within a channel or chamber
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001

Abstract

A mechanical actuator system for performing an assay on a disposable diagnostic cartridge having a plurality of fluid-containing blisters includes a body configured to carry the disposable diagnostic cartridge in stationary relation thereon. A lead screw is operably supported by the body and a drive motor is operably connected to the lead screw. A carriage is threadedly coupled to the lead screw, with the carriage having upper and lower wall spaced from one another. A roller is operably carried by the upper wall of the carriage. The roller is spaced from the lower wall for passage of the diagnostic cartridge between the roller and the lower wall. A driven gear is operably coupled to the roller in meshed engagement with the lead screw. Actuation of the drive motor causes the lead screw to rotate, thereby translating the carriage along the lead screw and concurrently causing the driven gear to rotate the roller.

Claims

1. A mechanical actuator system for performing an assay on a disposable diagnostic cartridge having a plurality of fluid-containing blisters, comprising:

a body having a base and a pair of support flanges extending upwardly from said base in spaced relation from one another, said body being configured to carry the disposable diagnostic cartridge in stationary relation thereon;

at least one lead screw extending between opposite ends, one of said opposite ends being operably supported by one of said flanges and the other of said opposite ends being operably supported by the other of said flanges;

a drive motor operably connected to one of said opposite ends of said at least one lead screw;

at least one carriage threadedly coupled to a respective one of said at least one lead screw;

at least one roller operably carried by said at least one carriage for rotation to compress at least one of the fluid-containing blisters on the diagnostic cartridge; and

a driven gear operably coupled to said at least one roller for conjoint rotation therewith, said driven gear being configured in meshed engagement with one of said at least one lead screw,

wherein actuation of said drive motor causes said at least one lead screw to rotate, thereby causing said at least one carriage to translate along said at least one lead screw and concurrently causing said driven gear and said at least one roller to rotate.

2. The mechanical actuator system of claim 1, wherein said at least one carriage has a window sized for receipt of said roller therein.

3. The mechanical actuator system of claim 1, wherein said at least one carriage has a slot and further comprising a guide rod received in said slot, said guide rod extending parallel with said at least one lead screw and countering rotational forces imparted on said at least one carriage by said lead screw extending therethrough.

4. The mechanical actuator system of claim 3, wherein said guide rod has opposite ends supported by said support flanges.

5. The mechanical actuator system of claim 1, wherein said carriage has upper and lower walls spaced from one another by a U-shaped cavity, said window being formed in said upper wall, with said roller being spaced from said lower wall for receipt of the disposable diagnostic cartridge between said roller and said lower wall.

6. The mechanical actuator system of claim 5, further comprising a low friction material disposed on said lower wall, said low friction material facing said roller for receipt of the disposable diagnostic cartridge between said roller and said low friction material.

7. The mechanical actuator system of claim 5, further comprising a toggle actuator pivotally supported on said lower wall for operable pivotal engagement with a toggle lobe and a blister pierce member on the disposable diagnostic cartridge.

8. The mechanical actuator system of claim 1, wherein said at least one roller includes a pair of rollers operably carried by said at least one carriage.

9. A mechanical actuator system for performing an assay on a disposable diagnostic cartridge having a plurality of fluid-containing blisters, comprising:

a body configured to carry the disposable diagnostic cartridge in stationary relation thereon;

at least one lead screw operably supported by said body;

a drive motor operably connected to said at least one lead screw;

a carriage threadedly coupled to said lead screw, said carriage having upper and lower wall spaced from one another;

a roller operably carried by said upper wall of said carriage, said roller being in spaced relation from said lower wall for passage of the diagnostic cartridge between said roller and said lower wall; and

a driven gear operably coupled to said roller, said driven gear being configured in meshed engagement with said lead screw, wherein actuation of said drive motor causes said lead screw to rotate, thereby causing said carriage to translate along said lead screw and concurrently causing said driven gear to rotate said roller.

10. The mechanical actuator system of claim 9, wherein said carriage has a through window formed in said upper wall, said window being sized for receipt of said roller therein.

11. The mechanical actuator system of claim 9, wherein said carriage has a slot and further comprising a guide rod received in said slot, said guide rod countering rotational forces imparted on said carriage by said lead screw.

12. The mechanical actuator system of claim 9, further comprising a low friction material disposed on said lower wall, said low friction material facing said roller for receipt of the disposable diagnostic cartridge between said roller and said low friction material.

13. The mechanical actuator system of claim 9, further comprising a toggle actuator pivotally supported on said lower wall for operable pivotal engagement with a toggle lobe and a blister pierce member on the disposable diagnostic cartridge.