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LOX and LOXL2 inhibitors and uses thereof

  • US 10,494,443 B2
  • Filed: 11/02/2016
  • Issued: 12/03/2019
  • Est. Priority Date: 08/02/2007
  • Status: Active Grant
First Claim
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1. An isolated monoclonal antibody or antigen binding fragment thereof that specifically binds to a lysyl oxidase-like 2 (LOXL2) protein and comprises a heavy chain variable region comprising complementarity determining region (CDR)1, CDR2 and CDR3 comprising the amino acid sequences set forth as SEQ ID NOs:

  • 41, 42, and 70, respectively, and a light chain variable region comprising CDR1, CDR2 and CDR3 comprising the amino acid sequences set forth as SEQ ID NOs;

    57, 58, and 59, respectively.

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