Compositions and methods for treating bone, joints and cartilage
First Claim
1. A method for treating a joint, comprising the step of administering into a joint of a subject a composition comprising isolated Non-Bulbar Dermal Sheath (NBDS) cells, where the NBDS cells have been isolated from an outer dermal sheath of a hair follicle, where the outer dermal sheath of the hair follicle is located above the bulbar portion of the hair root but below the base of the sebaceous gland canal.
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Abstract
Briefly stated, the present invention provides compositions and methods for treating or preventing joint injuries utilizing hair follicle derived Non-Bulbar Dermal Sheath (“NDBS”) cells. Within one aspect of the invention methods are provided for isolating NBDS cells, comprising the steps of: (a) preparing vital hair; (b) cleaving the hair prepared in step (a) to remove the hair follicle bulb; (c) isolating Non-Bulbar Dermal Sheath tissue; and (d) cultivating the isolated Non-Bulbar Dermal sheath tissue to produce NBDS cells. Within one embodiment of the invention the vital hair is obtained by full skin biopsy from the occipital scalp of a subject.
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Citations
20 Claims
- 1. A method for treating a joint, comprising the step of administering into a joint of a subject a composition comprising isolated Non-Bulbar Dermal Sheath (NBDS) cells, where the NBDS cells have been isolated from an outer dermal sheath of a hair follicle, where the outer dermal sheath of the hair follicle is located above the bulbar portion of the hair root but below the base of the sebaceous gland canal.
Specification