Peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
First Claim
1. A method of eliciting an immune response in a patient who has cancer, comprising administering to the patient a population of activated T cells that selectively recognize cells which present a peptide consisting of the amino acid sequence of HLLEDIAHV (SEQ ID NO:
- 3),wherein the activated T cells are produced by contacting T cells with the peptide loaded human class I or II MEW molecules expressed on the surface of an antigen-presenting cell for a period of time sufficient to activate the T cells;
wherein said cancer is selected from the group consisting of liver cancer, breast cancer, uterine cancer, gallbladder cancer, bile duct cancer, acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), ovarian cancer, and esophageal cancer.
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Abstract
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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Citations
20 Claims
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1. A method of eliciting an immune response in a patient who has cancer, comprising administering to the patient a population of activated T cells that selectively recognize cells which present a peptide consisting of the amino acid sequence of HLLEDIAHV (SEQ ID NO:
- 3),
wherein the activated T cells are produced by contacting T cells with the peptide loaded human class I or II MEW molecules expressed on the surface of an antigen-presenting cell for a period of time sufficient to activate the T cells; wherein said cancer is selected from the group consisting of liver cancer, breast cancer, uterine cancer, gallbladder cancer, bile duct cancer, acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), ovarian cancer, and esophageal cancer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- 3),
Specification