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Peptides and combination of peptides for use in immunotherapy against various tumors

  • US 10,501,522 B2
  • Filed: 12/19/2017
  • Issued: 12/10/2019
  • Est. Priority Date: 03/27/2015
  • Status: Active Grant
First Claim
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1. A method of eliciting an immune response in a patient who has cancer, comprising administering to the patient a population of activated T cells that selectively recognize cells which present a peptide consisting of the amino acid sequence of SLLNQPKAV (SEQ ID NO:

  • 235),wherein the activated T cells are produced by contacting T cells with the peptide loaded human class I or II MHC molecules expressed on the surface of an antigen-presenting cell for a period of time sufficient to activate the T cells,wherein said cancer is selected from the group consisting of glioblastoma (GB), non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), ovarian cancer (OC), melanoma (MEL), colorectal cancer (CRC), pancreatic cancer (PC), esophageal cancer (OSCAR), small cell lung cancer (SCLC), urinary bladder cancer (UBC), uterine cancer (UTC), breast cancer (BRCA), gallbladder cancer and cholangiocarcinoma (GBC CCC), acute myeloid leukemia (AML), and Non-Hodgkin lymphoma (NHL).

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