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Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use

  • US 10,501,558 B2
  • Filed: 06/23/2017
  • Issued: 12/10/2019
  • Est. Priority Date: 06/26/2012
  • Status: Active Grant
First Claim
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1. An antibody fragment of the IgG class comprising an Fc protein, wherein the Fc protein comprises a polypeptide chain having one or more non-natural amino acid residues at specific sites selected from the group consisting of heavy chain residues H241 and H222 according to the EU index of Kabat in the polypeptide chain, or a post-translationally modified variant or an aglycosylated variant thereof,wherein the non-natural amino acid residue is selected from the group consisting of:

  • ortho-substituted tyrosine, meta-substituted tyrosine, para-substituted phenylalanine, ortho-substituted phenylalanine, and meta-substituted phenylalanine.

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