Lipid nanoparticle compositions and methods for mRNA delivery
First Claim
1. A method for pulmonary delivery of messenger RNA (mRNA) for in vivo production of a protein in the lung comprising administering via inhalation from a nebulizer to the lung of a subject, a composition comprising an mRNA that encodes the protein,wherein the mRNA is encapsulated within a lipid nanoparticle comprising one or more PEG-modified lipids, andwherein the administering of the composition results in detectable levels of the protein at least 72 hours after administration in the subject'"'"'s lung.
3 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
494 Citations
20 Claims
-
1. A method for pulmonary delivery of messenger RNA (mRNA) for in vivo production of a protein in the lung comprising administering via inhalation from a nebulizer to the lung of a subject, a composition comprising an mRNA that encodes the protein,
wherein the mRNA is encapsulated within a lipid nanoparticle comprising one or more PEG-modified lipids, and wherein the administering of the composition results in detectable levels of the protein at least 72 hours after administration in the subject'"'"'s lung.
Specification