Blood component measuring device, method for measuring blood component, and bio-sensor

• US 10,509,005 B2
• Filed: 10/05/2017
• Issued: 12/17/2019
• Est. Priority Date: 12/12/2012
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: PHC Holdings Corporation
• Inventors: Fujiwara, Masaki, Yamamoto, Tomohiro
• Primary Examiner(s): Noguerola, Alexander S
• Application Number:
  US15/726,077
• Publication Number:
  US 20180038819A1
• Time in Patent Office: 803 Days
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

Provided is a blood component measuring device or the like that can further suppress the measurement error of a blood component. The device detects an oxidation-reduction current generated by oxidation-reduction when a first voltage is applied to a first electrode pair 21, 22 of a biosensor 1, and converts the oxidation-reduction current (glucose response value) into a glucose conversion value. The device detects a current generated when a second voltage is applied to a second electrode pair 23, 24 of the biosensor 1, and converts the detected current (blood cell amount response value) into a blood cell amount conversion value. The glucose response value is measured more than once and the blood cell amount response value is also measured more than once within a predetermined period after the introduction of the blood into the biosensor 1. A CPU 72 corrects the glucose conversion value measured within the predetermined period based on at least a part of a plurality of glucose conversion values and a plurality of blood cell amount conversion values obtained from the results of measurement.

Claims

1. A method for measuring a blood component that measures a blood component amount with a biosensor in which blood is introduced, and a blood component contained in the blood is oxidized and reduced by an oxidoreductase,

the method comprising:

measuring a first current value generated when a first voltage is applied to a first electrode pair of the biosensor,

measuring multiple times a second current value generated when a second voltage is applied to a second electrode pair of the biosensor multiple times, and

correcting the measured first current value based on at least a part of the measured first and second current values,

wherein measuring the first current value is conducted by

applying the first voltage to the first electrode pair during a predetermined period after introduction of the blood to the biosensor, and

detecting the current at the predetermined timing for detection of the first current,

measuring the second current value multiple times is conducted by

applying a pulse of the second voltage to the second electrode pair during a predetermined short period from the measuring of the second current and during a predetermined timing for detection of the second current, and

detecting the current corresponding to each of the second currents.

2. The method for measuring a blood component according to claim 1, wherein the second voltage is applied to the second electrode pair only at the timing of the measurement of the second current value in the predetermined period while the first voltage is being applied to the first electrode pair.