Intragastric device for treating obesity

• US 10,512,557 B2
• Filed: 11/16/2016
• Issued: 12/24/2019
• Est. Priority Date: 06/13/2010
• Status: Active Grant

• Current Assignee: SynerZ Medical, Inc.
• Original Assignee: W. L. Gore & Associates (W.L. Gore & Associates)
• Inventors: Sharma, Virender K.
• Primary Examiner(s): Louis, Richard G
• Application Number:
  US15/353,219
• Publication Number:
  US 20170056226A1
• Time in Patent Office: 1,133 Days
• Field of Search: None
• CPC Class Codes: A61F 5/0036 Intragastrical devices
• CPC Class Codes: A61F 5/0076 preventing normal digestion, e.g. Bariatric or gastric sleeves
• CPC Class Codes: A61F 5/0079 Pyloric or esophageal obstructions
• CPC Class Codes: A61F 5/0089 Instruments for placement or removal

Abstract

A gastrointestinal device for treating obesity includes a three-dimensional porous structure configurable between a compressed pre-deployment configuration to facilitate delivery and an expanded post-deployment configuration. The porous structure includes a first opening at its proximal end and a larger second opening at its distal end. The porous structure also includes a sleeve coupled to its distal end. Optionally, the device further includes a suture at the proximal end of the wire mesh structure to facilitate retrieval and an anti-migration component positioned at the junction of the porous structure with the sleeve. The porous structure is deployed in a patient'"'"'s stomach such that the anti-migration component sits proximal to the patient'"'"'s pylorus and prevents migration of the entirety of the device into and through the pylorus. The sleeve extends through the pylorus, into the duodenum and ends in the duodenum or jejunum. Food enters the device from the first opening at the proximal end of the porous structure, passes through the porous structure and sleeve, and exits at the distal end of the sleeve. The device treats obesity by providing a relatively immovable volume occupying structure in the stomach and a bypass for food past the pylorus and proximal portion of the small intestine. Optionally, the device further acts to slow the passage of food through the digestive tract. Patients with the device experience satiety more quickly and have a prolonged sensation of satiety.

Claims

1. A gastrointestinal device comprising:

a three dimensional structure defining an internal volume and having a proximal and a distal end, said proximal end having at least one first opening and said distal end having at least one second opening;

an anti-migration component positioned at said distal end of said three dimensional structure; and

an elongate sleeve coupled to said anti-migration component and extending distally therefrom,

wherein the three dimensional structure is a wire mesh structure, the anti-migration component comprises an extension of the wire mesh structure, and the wire mesh structure has a first weave with a first compressibility and the anti-migration component has a second weave with a second compressibility different from the first compressibility.

2. The gastrointestinal device of claim 1, wherein said wire mesh structure is configurable between a compressed configuration and an expanded configuration.

3. The gastrointestinal device of claim 1, wherein said expanded configuration is one of a cylinder, ovoid, sphere, bean, stomach shape, football, cube or cuboid.

4. The gastrointestinal device of claim 1, wherein said anti-migration component is coupled to said wire mesh structure.

5. The gastrointestinal device of claim 1, wherein said sleeve extends over said anti-migration component.

6. The gastrointestinal device of claim 1, wherein said elongate sleeve is in fluid communication with said porous structure.

7. The gastrointestinal device of claim 1, wherein said second opening is larger than said first opening.

8. The gastrointestinal device of claim 1, wherein said sleeve comprises at least one of silicone, latex, parylene, polyurethane, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (PTFE), fluorinated ethylene-propylene, and polyethylene terephthalate.

9. The gastrointestinal device of claim 1, wherein said anti-migration component has a shape comprising any one of donut, discoid sloping proximally, discoid sloping distally, flat discoid or circular, a half bumper, a full bumper, a flower shape, a saucer shape, or a spherical shape.

10. The gastrointestinal device of claim 1, wherein said three dimensional structure has an ovoid or spherical shape.

26. The gastrointestinal device of claim 1, wherein the three dimensional structure is configured to store ingested food such that the three dimensional structure undergoes a meal-induced dynamic weight change and a weight of the gastrointestinal device increases when storing the ingested food.

27. The gastrointestinal device of claim of claim 26, wherein the three dimensional structure is configured to release the ingested food over time through the at least one second opening such that the three dimensional structure decreases in weight over time as the ingested food is released from of the three dimensional structure.

11. A gastrointestinal device comprising:

a porous structure configurable between a compressed pre-deployment configuration and an expanded post-deployment configuration;

an anti-migration collar proximate a distal end of said porous structure; and

an elongate sleeve coupled to a distal end of said porous structure,

wherein the porous structure is a wire mesh structure having a first weave with a first compressibility and the anti-migration component has a second weave with a second compressibility different from the first compressibility.

12. The gastrointestinal device claim 11, wherein said anti-migration component comprises an extension of said wire mesh structure.

13. The gastrointestinal device of claim 12, wherein said sleeve extends over said anti-migration component.

14. The gastrointestinal device of claim 11, wherein said anti-migration component is coupled to said wire mesh structure.

15. The gastrointestinal device of claim 14, wherein said sleeve extends over said anti-migration component.

16. The gastrointestinal device of claim 11, wherein said elongate sleeve is in fluid communication with said porous structure.

17. The gastrointestinal device of claim 11, wherein said sleeve comprises at least one of silicone, latex, parylene, polyurethane, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (PTFE), fluorinated ethylene-propylene, and polyethylene terephthalate.

18. The gastrointestinal device of claim 11, wherein said anti-migration component has a shape comprising any one of donut, discoid sloping proximally, discoid sloping distally, flat discoid or circular, a half bumper, a full bumper, a flower shape, a saucer shape, or a spherical shape.

19. The gastrointestinal device of claim 11, wherein said three dimensional structure has an ovoid or spherical shape.

20. A gastrointestinal device comprising:

a substantially spherical wire mesh structure having a proximal end, a distal end, and an opening at said distal end;

an anti-migration component coupled to said opening at said distal end via a wire mesh footing; and

a sleeve comprising an elongate tubular body coupled to and extending distally from said anti-migration member,

wherein the substantially spherical wire mesh structure has a first weave with a first compressibility and the anti-migration component has a second weave with a second compressibility different from the first compressibility.

21. The gastrointestinal device of claim 20, further comprising an opening at said proximal end.

22. The gastrointestinal device of claim 21, wherein said opening at said distal end is larger than said opening at said proximal end.

23. The gastrointestinal device of claim 20, wherein said anti-migration component comprises a rounded bumper shape configuration.

24. The gastrointestinal device of claim 20, wherein said sleeve comprises at least one of silicone, latex, parylene, polyurethane, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (PTFE), fluorinated ethylene-propylene, and polyethylene terephthalate.

25. The gastrointestinal device of claim 20, wherein said sleeve extends over said anti-migration component.