Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
First Claim
1. A method for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease, comprising:
- providing in the gut of an individual a population of beneficial bacteria selected from the group consisting of Lactobacillus species;
administering at least 6 grams per day of fiber to the individual to maintain a therapeutically effective amount of the beneficial bacteria in the gut of the individual; and
increasing the levels of Roseburia, while reducing the levels of Akkermansia spp. in the individual'"'"'s gut microbiome.
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Abstract
A method for reducing the likelihood of developing non-alcoholic steatohepatitis (NASH) in an individual diagnosed with non-alcoholic fatty liver disease involves providing in the gut of an individual a population of beneficial bacteria selected from the group consisting of Lactobacillus species, and at least 6 grams per day of fiber to the individual to maintain a therapeutically effective amount of the beneficial bacteria in the gut of the individual. In certain embodiments, monoacylglycerolacyltransferase-3 (MGAT3) synthesis is inhibited to lower triacylglycerol (TAG) production, while in others, expression of diacylglycerolacyltransferase-2 (DGAT-2) is inhibited. The beneficial bacteria are preferably modified to produce increased amounts of butyrate and are also encapsulated in a frangible enclosure. Levels of Roseburia are preferably increased while the levels of Akkermansia spp. in the individual'"'"'s gut microbiome are reduced.
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Citations
4 Claims
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1. A method for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease, comprising:
- providing in the gut of an individual a population of beneficial bacteria selected from the group consisting of Lactobacillus species;
administering at least 6 grams per day of fiber to the individual to maintain a therapeutically effective amount of the beneficial bacteria in the gut of the individual; and
increasing the levels of Roseburia, while reducing the levels of Akkermansia spp. in the individual'"'"'s gut microbiome. - View Dependent Claims (2, 3, 4)
- providing in the gut of an individual a population of beneficial bacteria selected from the group consisting of Lactobacillus species;
Specification