Bioadhesive hydrogels
First Claim
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1. A bioadhesive comprising:
- a crosslinked biodegradable hydrogel that includes a plurality of oxidized and acrylated or methacrylated natural polymer macromers crosslinked with a plurality of branched poly(ethylene glycol) macromers, wherein the bioadhesive upon application to injured tissue mechanically joins or seals the injured tissue.
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Abstract
A bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized, acrylated or methacrylated, natural polymer. Bioadhesives are natural or synthetic materials that can be used for soft tissue repair to create a seal preventing leakage of biological fluids or to reinforce anatomic integrity as an attractive alternative to sutures and staples. The most widely used bioadhesives are fibrin, cyanoacrylates, and albumin-glutaraldehyde bioadhesives.
4 Citations
24 Claims
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1. A bioadhesive comprising:
- a crosslinked biodegradable hydrogel that includes a plurality of oxidized and acrylated or methacrylated natural polymer macromers crosslinked with a plurality of branched poly(ethylene glycol) macromers, wherein the bioadhesive upon application to injured tissue mechanically joins or seals the injured tissue.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A bioadhesive comprising:
- a dual crosslinked biodegradable hydrogel that includes a plurality of oxidized and acrylated or methacrylated polysaccharide macromers crosslinked with a plurality of branched poly(ethylene glycol) macromers, wherein the bioadhesive upon application to injured tissue mechanically joins or seals the injured tissue.
- View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A bioadhesive comprising:
- a dual crosslinked biodegradable hydrogel that includes a plurality of oxidized and acrylated or methacrylated alginate macromers crosslinked with a plurality of branched poly(ethylene glycol) macromers, wherein the bioadhesive upon application to injured tissue mechanically joins or seals the injured tissue.
- View Dependent Claims (19, 20, 21, 22, 23, 24)
Specification