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Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase

  • US 10,513,499 B2
  • Filed: 06/02/2017
  • Issued: 12/24/2019
  • Est. Priority Date: 08/29/2014
  • Status: Active Grant
First Claim
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1. A method of treating a disease or disorder associated with reduced nicotinamide adenine dinucleotide (NAD+) levels selected from the group consisting of a metabolic disorder, a neurodegenerative disease, a chronic inflammatory disease, a fatty liver disease, and a kidney disorder in a subject, the method comprising administering to the subject suffering from or susceptible to developing a disease or disorder associated with reduced NAD+ levels a therapeutically effective amount of a compound represented by Formula (I):

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