Monitor and system for monitoring an organism

• US 10,517,516 B2
• Filed: 05/02/2014
• Issued: 12/31/2019
• Est. Priority Date: 05/02/2013
• Status: Active Grant

• Current Assignee: Atonarp Inc.
• Original Assignee: Atonarp Inc.
• Inventors: Murthy, Prakash Sreedhar
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US14/888,093
• Publication Number:
  US 20160157757A1
• Time in Patent Office: 2,069 Days
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G01N 21/65 Raman scattering

Abstract

Provided is a monitor for monitoring the condition of the interior of a living organism from the surface of the living organism. The monitor is provided with: a probe which includes an observation window and is attached to the organism surface; a unit which irradiates, with a laser, at least a portion of an observation region; a unit which detects scattered light resulting from the laser irradiation; a Doppler analysis unit and a SORS analysis unit which narrow down the observation spots to a first observation spot; and a CARS analysis unit which obtains the optical spectrum for at least one component, and outputs first information indicating the condition of the organism interior on the basis of the intensity of the spectrum.

Claims

1. A monitor that is configured to monitor a state of an organism internal part from a surface of the organism, comprising:

a probe including an observation window configured to attach to the surface of the organism;

a laser emission unit that is configured to emit laser beams that have a wavelength of a stokes light and a wavelength of a pump light onto at least part of an observation region on the surface of the organism accessed via the observation window;

a detector that is configured to detect CARS light caused by emission of the laser beams from each of a plurality of observation spots that are either intermittently dispersed in two dimensions in the observation region or are continuously formed so as to scan the observation region;

an optical system that is configured to intersect the stokes light and the pump light at a depth in the organism; and

a CARS analyzing unit that limits the detected CARS light to CARS light from first observation spots from which the CARS light is evaluated so that information on a target part of the organism internal part is obtained, wherein the CARS analyzing unit is also configured to change the depth of intersection of the stokes light and the pump light to obtain a depth profile of the organism to get a depth profile; and

an organism information generating unit that acquires spectra of at least one component from the first observation spots or peripheries of the first observation spots based on the depth profile and outputs first information showing the state of the organism internal part based on intensities of the spectra.

2. The monitor according to claim 1,

wherein the at least one component includes a first component for a plurality of parts at different depths from the surface of the organism at the first observation spots or the peripheries of the first observation spots and the CARS analyzing unit further limits or updates the first observation spots based on the intensity of the spectra of the first component.

3. The monitor according to claim 1,

wherein the probe includes an output unit that guides the laser beams from the laser emission unit to each of the plurality of spots selectively.

4. The monitor according to claim 1,

wherein the probe includes an input unit that guides the CARS light from each of the plurality of observation spots to the detector unit.

5. The monitor according to claim 1,

wherein the plurality of observation spots are set at intervals of 1 to 1000 μ

m in the observation region.

6. The monitor according to claim 1,

wherein the plurality of observation spots are set at intervals of 10 to 100 μ

m in the observation region.

7. The monitor according to claim 1,

wherein the probe is configured to attach the observation window to the surface of the organism via a diffusive porous membrane.

8. A system comprising:

the monitor according to claim 1; and

a delivery unit that provides a physiologically active substance to the organism based on the first information.

9. The system according to claim 8 further comprising:

a behavior monitoring unit that acquires or predicts an external state of the organism; and

a unit that controls an amount or type of physiologically active substance provided to the organism from the delivery unit according to information from the behavior monitoring unit in addition to the first information.

10. The system according to claim 8, further comprising a cloud service unit that is configured to allow remote monitoring to monitor the first information and an operating state of the delivery unit.

11. A control method for a system including a monitor that monitors a state of an organism internal part from a surface of the organism,

the monitor including:

a probe including an observation window configure to attach to the surface of the organism;

a laser emission unit that is configured to emit laser beams that have a wavelength of a stokes light and a wavelength of a pump light onto at least part of an observation region on the surface of the organism accessed via the observation window;

a detector that is configured to detect CARS light caused by emission of the laser beams from each of a plurality of observation spots that are either intermittently dispersed in two dimensions in the observation region or are continuously formed so as to scan the observation region; and

an optical system that is configured to intersect the stokes light and the pump light at a depth in the organism;

wherein the method comprises;

limiting the detected CARS light to CARS light from first observation spots from which the CARS light is evaluated so that information on a target part of the organism internal part is obtained;

changing the depth of intersection of the stokes light and the pump light to obtain a depth profile of the organism to get a depth profile; and

acquiring spectra of at least one component from the first observation spots or peripheries of the first observation spots based on the depth profile and outputting first information showing the state of the organism internal part based on intensities of the spectra.

12. The method according to claim 11,

wherein the at least one component includes a first component for a plurality of parts at different depths from the surface of the organism at the first observation spots or the peripheries of the first observation spots and the limiting includes further limiting or updating the first observation spots based on the intensity of the spectra of the first component.

13. The method according to claim 11,

wherein the system further includes a delivery unit that provides a physiologically active substance to the organism,

and the method further comprises selecting a physiologically active substance among the physiologically active substances and an amount to be delivered by the delivery unit based on the first information.

14. The method according to claim 13,

wherein the system further includes a behavior monitoring unit that acquires or predicts an external state of the organism;

and

in the selecting, the amount or type of the physiologically active substance delivered by the delivery unit is selected based on information on the external state in addition to the first information.