Methods and systems for inhibiting foreign-body responses in diabetic patients
First Claim
1. A system for delivering insulin to a diabetic patient at a single site of infusion over a period of time, the system comprising:
- a medication reservoir comprising an insulin solution;
a cannula adapted for subcutaneous insertion into a tissue of a diabetic patient at the single site of infusion;
a fluid conduit in operable contact with the medication reservoir and the cannula and adapted to deliver insulin from the medication reservoir to the single site of infusion; and
a heparin composition in operable contact with the fluid conduit that inhibits inflammation at the single site of infusion so as to inhibit insulin site loss; and
wherein the system delivers an amount of heparin sufficient to inhibit inflammation at the single site of infusion for a period of time of at least 4 days.
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Accused Products
Abstract
Methods and devices are provided for reducing a diabetic patient'"'"'s foreign body immune response, including infusion site-loss and/or occlusion. Such foreign body responses are associated with the treatment of the diabetic patient where the treatment requires subcutaneous implantation of a foreign body, such as a cannula or catheter. In certain embodiments of the invention, a response-inhibiting agent is administered to a patient at the site of cannula/catheter insertion, thereby facilitating delivery of insulin to the diabetic patient and mitigating site-loss and/or occlusion over a period of time.
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Citations
22 Claims
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1. A system for delivering insulin to a diabetic patient at a single site of infusion over a period of time, the system comprising:
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a medication reservoir comprising an insulin solution; a cannula adapted for subcutaneous insertion into a tissue of a diabetic patient at the single site of infusion; a fluid conduit in operable contact with the medication reservoir and the cannula and adapted to deliver insulin from the medication reservoir to the single site of infusion; and a heparin composition in operable contact with the fluid conduit that inhibits inflammation at the single site of infusion so as to inhibit insulin site loss; and
wherein the system delivers an amount of heparin sufficient to inhibit inflammation at the single site of infusion for a period of time of at least 4 days. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for mitigating a foreign body response in a diabetic patient receiving insulin at a single infusion site over a time period of at least three days, the method comprising:
administering a site loss mitigating agent comprising heparin in combination with insulin at the single infusion site so as to inhibit insulin site loss, wherein the site loss mitigating agent mitigates inflammation at the single infusion site thereby inhibiting a foreign body response in a diabetic patient; and
wherein the system delivers an amount of a site loss mitigating agent sufficient to inhibit inflammation at the single site of infusion for at least 4 days.- View Dependent Claims (10, 11, 12, 13)
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14. A method for delivering insulin to a diabetic patient at a single site of infusion over a period of at least four days, the method comprising infusing the insulin at the single site of infusion using a system comprising:
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a medication reservoir comprising an insulin solution; a cannula adapted for subcutaneous insertion into a tissue of a diabetic patient at the single site of infusion; a fluid conduit in operable contact with the medication reservoir and the cannula and adapted to deliver insulin from the medication reservoir to the single site of infusion; heparin that inhibits-inflammation at the single site of infusion so as to inhibit insulin site loss; so that insulin is delivered to the diabetic patient; and
wherein the heparin is administered according to an extended release profile that delivers heparin to the single site of infusion in a manner sufficient to inhibit inflammation at the single site of infusion for at least 6 days. - View Dependent Claims (15, 16, 17)
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18. A system for delivering insulin to a diabetic patient at a single site of infusion over a period of time, the system comprising:
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a medication reservoir comprising an insulin solution; a cannula adapted for subcutaneous insertion into a tissue of a diabetic patient at the single site of infusion; a fluid conduit in operable contact with the medication reservoir and the cannula and adapted to deliver insulin from the medication reservoir to the single site of infusion; and a site loss mitigation composition disposed in operable contact with the fluid conduit inflammation at the single site of infusion so as to inhibit insulin site loss; and
wherein the site loss mitigation composition comprises heparin in an amount sufficient to administer between 0.1 and 80 U/kg/day to the diabetic patient so as to inhibit site loss in the diabetic patient for at least 4 days. - View Dependent Claims (19, 20, 21, 22)
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Specification