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Methods of lowering blood glucose levels in a mammal

  • US 10,517,901 B2
  • Filed: 04/24/2018
  • Issued: 12/31/2019
  • Est. Priority Date: 03/02/2006
  • Status: Active Grant
First Claim
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1. A method of lowering blood glucose levels in a human in need thereof, said method comprising the steps of:

  • a) transplanting a cell culture comprising, (i) human pancreatic duodenum homeobox 1 (PDX-1) positive pancreatic endoderm cells and (ii) human endocrine precursor cells that express neurogenin 3 (NEUROG3) into the human; and

    b) maturing in vivo the transplanted cells of step a) into insulin secreting cells, wherein the insulin secreting cells secrete insulin in response to glucose stimulation, thereby lowering the blood glucose levels of the human.

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