Method and apparatus for fluid delivery

• US 10,518,075 B2
• Filed: 08/17/2015
• Issued: 12/31/2019
• Est. Priority Date: 03/13/2006
• Status: Active Grant

• Current Assignee: Renishaw PLC
• Original Assignee: Renishaw PLC
• Inventors: Gill, Steven Streatfield
• Primary Examiner(s): Mehta, Bhisma
• Assistant Examiner(s): Darb, Hamza A
• Application Number:
  US14/827,720
• Publication Number:
  US 20150352347A1
• Time in Patent Office: 1,597 Days
• CPC Class Codes: A61M 2039/0205 for injecting media
• CPC Class Codes: A61M 2039/0229 having means for facilitating assembling, e.g. snap-fit housing or modular design
• CPC Class Codes: A61M 2039/0232 having means for facilitating the insertion into the body
• CPC Class Codes: A61M 2039/025 through bones or teeth, e.g. through the skull
• CPC Class Codes: A61M 2039/1066 having protection means, e.g. sliding sleeve to protect connector itself, shrouds to protect a needle present in the connector, protective housing, isolating sheath
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: A61M 39/10 Tube connectors; Tube couplings A61M39/02 takes precedence; connecting needles to syringes or hubs A61M5/34; connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body

Abstract

A method for delivering fluid to a brain of a subject is disclosed. This method includes the steps of: making one or more incisions in a subject; implanting one or more catheters in the brain of the subject; subcutaneously implanting a first part of a modular fluid delivery apparatus in the subject, the first part of the modular fluid delivery apparatus comprising a first length of tubing having a first end and a second end, the first end having a first fluid connector portion attached thereto and the second end being connected to the one or more catheters; and closing the one or more incisions such that the first part of the modular fluid delivery apparatus and the one or more catheters are entirely subcutaneously implanted within the subject.

Claims

1. A method for delivering fluid to a brain of a subject, the method comprising the steps of:

making a first incision in the subject in order to implant one or more catheters in the brain of the subject at a first location;

making a second incision in the subject at a second location different from the first location;

subcutaneously implanting a first part of a modular fluid delivery apparatus in the subject, the first part of the modular fluid delivery apparatus comprising a first length of tubing having a first end and a second end, the first end having a first fluid connector portion attached thereto and the second end being connected to the one or more catheters;

closing the first and second incisions such that the first part of the modular fluid delivery apparatus and the one or more catheters are entirely subcutaneously implanted within the subject; and

prior to the step of closing the second incision, accessing the one or more implanted catheters through the second incision by;

(i) providing a second part of the modular fluid delivery apparatus, the second part comprising a second length of tubing having a third end comprising a second fluid connector portion;

(ii) connecting the first fluid connector portion to the second fluid connector portion; and

(iii) delivering the fluid to a tissue of the brain by pumping the fluid to the one or more implanted catheters through the first and second parts of the modular fluid delivery apparatus.

2. The method according to claim 1, wherein the first fluid connector portion and the second fluid connector portion are connected without passing a needle through skin of the subject.

3. A method for delivering fluid to a brain of a subject, the method comprising the steps of:

making a first incision in the subject in order to implant one or more catheters in the brain of the subject at a first location;

making a second incision in the subject at a second location different from the first location;

subcutaneously implanting a first part of a modular fluid delivery apparatus in the subject, the first part of the modular fluid delivery apparatus comprising a first length of tubing having a first end and a second end, the first end having a first fluid connector portion attached thereto and the second end being connected to the one or more catheters;

closing the first and second incisions such that the first part of the modular fluid delivery apparatus and the one or more catheters are entirely subcutaneously implanted within the subject; and

after the step of closing the second incision, making one or more further incisions in the subject at the second location to access the first fluid connector portion through the one or more further incisions, the one or more further incisions configured to allow connection of a second fluid connector portion to the first fluid connector portion.

4. The method according to claim 3, further comprising the subsequent steps of:

providing a second part of the modular fluid delivery apparatus, the second part comprising a second length of tubing having a third end comprising the second fluid connector portion;

connecting the first fluid connector portion to the second fluid connector portion; and

pumping fluid to the one or more implanted catheters through the first and second parts of the modular fluid delivery apparatus.

5. The method according to claim 4, further comprising the subsequent steps of:

disconnecting the first fluid connector portion from the second fluid connector portion;

completely withdrawing the second part of the modular fluid delivery apparatus from the subject; and

closing the one or more further incisions such that the first part of the modular fluid delivery apparatus and the one or more catheters are again subcutaneously implanted within the subject.

6. The method according to claim 3, wherein the second fluid connector portion and the first fluid connector portion are connected without passing a needle through skin of the subject.

7. The method according to claim 3, wherein connecting the first fluid connector portion to the second fluid connector portion includes passing a second length of tubing through the one or more further incisions.

8. A method for implanting an apparatus for delivering fluid to a brain of a subject, the method comprising the steps of:

making a first incision in a scalp of the subject at a first location in order to insert one or more catheters into the brain of the subject, each of the one or more catheters being connected by a length of tubing to a first fluid connector portion;

making a second incision in the subject at a second location different from the first location; and

closing the first and second incisions to thereby entirely subcutaneously bury the one or more catheters, the first fluid connector portion, and the length of tubing within the subject,

wherein, after the second incision has been surgically closed, the first fluid connector portion is configured to only be accessed through a subsequent surgical procedure that includes a step of making a further incision in the subject to uncover the first fluid connector portion, the further incision configured to allow connection of a second fluid connector portion to the first fluid connector portion.

9. The method according to claim 8, wherein the first fluid connector portion comprises a sealing member that prevents fluid egress from the length of tubing via the first fluid connector portion.

10. The method according to claim 8, wherein the first fluid connector portion comprises a self-sealing connector.

11. The method according to claim 10, wherein:

the self-sealing connector comprises a septum seal, and

the step of closing the first and second incisions further comprises locating the first fluid connector portion such that the septum seal only becomes accessible by performing the subsequent surgical procedure.

12. The method according to claim 8, further comprising the step of enclosing the first fluid connector portion in an implantable housing, wherein the step of closing the first and second incisions further comprises subcutaneously burying the implantable housing with the first fluid connector portion contained therein.

13. The method according to claim 8, wherein the step of inserting one or more catheters into the brain of the subject comprises inserting a plurality of said one or more catheters into the brain of the subject.

14. The method according to claim 13, further comprising an additional step of subcutaneously burying a fluid router, the fluid router being connected to the length of tubing of each of the plurality of said one or more catheters.

15. The method according to claim 8, further comprising a subsequent step of performing the subsequent surgical procedure that comprises making the further incision in the subject to uncover the first fluid connector portion.

16. The method according to claim 15, wherein the subsequent surgical procedure is performed a month or more after the one or more catheters, the first fluid connector portion, and the length of tubing have been subcutaneously implanted within the subject.

17. The method according to claim 15, further comprising the step of connecting the second fluid connector portion to the first fluid connector portion after the first fluid connector portion has been uncovered.

18. The method according to claim 17, wherein:

the second fluid connector portion is connected to a pump, and the method further comprises the step of pumping fluid to the one or more catheters through the first fluid connector portion and the second fluid connector portion.

19. The method according to claim 18, wherein the pump controls at least one of a flow rate and pressure of the fluid pumped to each of the one or more catheters to provide convection enhanced delivery of the fluid into the brain of the subject.

20. The method according to claim 15, further comprising a subsequent step of closing the further incision to entirely subcutaneously rebury the one or more catheters, the first fluid connector portion, and the length of tubing within the subject.