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Full spectrum anti-dengue antibody

  • US 10,519,220 B2
  • Filed: 01/11/2018
  • Issued: 12/31/2019
  • Est. Priority Date: 02/11/2014
  • Status: Active Grant
First Claim
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1. An antibody agent that:

  • (a) has a heavy chain variable region that shows at least 95% substantial sequence homology with that of heavy chain variable region of 4E5A (SEQ ID NO.

         29) and a light chain variable region that shows at least 95% substantial sequence homology with that of light chain variable region of 4E5A (SEQ ID NO.

         30); and

    (b) its heavy chain comprises one or more of the following mutations relative to 4E5A;

    VH_S26_del; and

    VH_G27_del orVH_G27A.

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