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Anti-PACAP antibody

  • US 10,519,225 B2
  • Filed: 09/20/2018
  • Issued: 12/31/2019
  • Est. Priority Date: 09/29/2017
  • Status: Active Grant
First Claim
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1. An antibody that binds human pituitary adenylate cyclase-activating peptide comprising a heavy chain variable region (HCVR) and a light chain variable region (LCVR), wherein the HCVR comprises complementarity determining regions (CDRs) HCDR1, HCDR2, and HCDR3 and the LCVR comprises CDRs LCDR1, LCDR2, and LCDR3, wherein the amino acid sequence of HCDR1 is SEQ ID NO:

  • 3, the amino acid sequence of HCDR2 is SEQ ID NO;

    4, the amino acid sequence of HCDR3 is SEQ ID NO;

    5, the amino acid sequence of LCDR1 is SEQ ID NO;

    6, the amino acid sequence of LCDR2 is SEQ ID NO;

    7, and the amino acid sequence of LCDR3 is SEQ ID NO;

    8, and whereinHCDR2 comprises aspartic acid, alanine, glutamic acid or glutamine at residue 13 of SEQ ID NO;

    4;

    HCDR3 comprises asparagine or threonine at residue 8 of SEQ ID NO;

    5;

    LCDR1 comprises serine or tryptophan at residue 7 of SEQ ID NO;

    6; and

    LCDR2 comprises leucine or phenylalanine at residue 7 of SEQ ID NO;

    7.

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