Methods of enhancing expression of somatostatin in pancreatic endocrine cells
First Claim
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1. A method of enhancing expression of somatostatin in pancreatic endocrine cells, comprising culturing pancreatic endoderm cells in medium comprising Activin A or Activin C, thereby generating pancreatic endocrine cells having enhanced expression of somatostatin.
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Abstract
The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
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13 Claims
- 1. A method of enhancing expression of somatostatin in pancreatic endocrine cells, comprising culturing pancreatic endoderm cells in medium comprising Activin A or Activin C, thereby generating pancreatic endocrine cells having enhanced expression of somatostatin.
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