Arrangement for preparing a plurality of samples for an analytical method

• US 10,520,519 B2
• Filed: 07/24/2015
• Issued: 12/31/2019
• Est. Priority Date: 07/29/2014
• Status: Active Grant

• Current Assignee: Joachim Gerstel
• Original Assignee: Joachim Gerstel
• Inventors: Gerstel, Joachim
• Primary Examiner(s): Wright, Kathryn
• Application Number:
  US15/329,866
• Publication Number:
  US 20170269112A1
• Time in Patent Office: 1,621 Days
• Field of Search: None
• CPC Class Codes: B01D 35/02 Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks, B01D35/05 takes precedence; water pipe system filters E03B3/18, E03B7/07; dirt catchers in sewers E03F; filters or strainers for pipe-lines in general B08B, E03F; object or dirt catching devices in sinks or the like E03C1/26; suction strainers or filters for pumps F04B53/005, F04D29/70
• CPC Class Codes: B01F 2101/23 Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
• CPC Class Codes: B01F 25/10 Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 3/0275 Interchangeable or disposable dispensing tips
• CPC Class Codes: B04B 11/043 Load indication with or without control arrangements
• CPC Class Codes: B04B 2011/046 Loading, unloading, manipulating sample containers
• CPC Class Codes: B04B 5/0414 comprising test tubes
• CPC Class Codes: B04B 5/0421 pivotably mounted
• CPC Class Codes: G01N 1/286 involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising microtomes G01N1/06; pulverising in general B02C; mixing in general B01F
• CPC Class Codes: G01N 2001/2873 Cutting or cleaving
• CPC Class Codes: G01N 2035/0405 manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
• CPC Class Codes: G01N 2035/0449 using centrifugal transport of liquid
• CPC Class Codes: G01N 2035/1025 Fluid level sensing
• CPC Class Codes: G01N 2035/103 using disposable tips
• CPC Class Codes: G01N 2035/1053 for separating part of the liquid, e.g. filters, extraction phase
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence
• CPC Class Codes: G01N 35/1011 : Control of the position or alignment of the transfer device
• CPC Class Codes: G01N 35/1079 : with means for piercing stoppers or septums
• CPC Class Codes: G01N 35/1097 : characterised by the valves valves in general F16K

Abstract

The invention relates to an arrangement for preparing a plurality of samples for an analytical method, comprising a carousel with a solid housing and moveable receiving parts for the sample containers; a control for controlling the receiving parts in the carousel; and a sample receiving device for providing the sample for the analytical method. Said arrangement is characterized in that one or more stations for preparing samples are provided on the carousel, the receiving parts for the sample containers of the carousel can be positioned on said stations. Said arrangement also comprises a centrifuge with pairs of opposite lying receiving parts provided for the sample containers, and said receiving parts are arranged such that they can move on the centrifuge for the sample holder such that a transfer of a sample holder between a receiving part in the carousel and a receiving part in the centrifuge can be carried out. The control takes place by the same control which is also provided for controlling the carousel.

Claims

1. An assembly for the preparation of a plurality of samples for an analytical method, comprising

a carousel with an inside, a center, and a steady housing;

carousel receptacles for sample vials arranged in a circle on said inside of said carousel and configured to be moved along said circle;

a sample taking device for providing a sample;

one or more stations at said carousel for sample preparation wherein said carousel receptacles are configured to be moved by a carousel movement and positioned at said one or more stations;

a centrifuge positioned in said center of said carousel and having a rotational axis;

centrifuge receptacles for said vials moveably fixed to said centrifuge and positioned in pairs opposite to each other wherein said centrifuge receptacles are formed by extendable gripping arms which are adjustable with respect to said rotational axis of said centrifuge for moving said centrifuge receptacles in a centrifuge movement; and

a control unit for controlling said carousel and centrifuge movement and movement of said vials in any of said receptacles for transferring a vial between carousel receptacle and a centrifuge receptacle using the extendable gripping arms.

2. The assembly of claim 1, and further comprising a sampling system for introducing said sample into an empty or prepared vial in said carousel.

3. The assembly of claim 2, and wherein said sampling system comprises an assembly for transferring samples provided on a sheet-like sample carrier into an empty or prepared vial with means for cutting said sheet-like sample carrier, and further comprising

a jet nozzle, the jet nozzle and/or said sheet-like sample carrier configured to carry out a movement;

a high pressure fluid source connected to said jet nozzle the high pressure fluid source configured to eject high pressure fluid from said jet nozzle; and

means for controlling said movement in such a way that selected portions of said sheet-like sample carrier can be cut out.

4. The assembly of claim 3, and wherein said high pressure fluid comprises at least one fluid used in said sample preparation method.

5. The assembly of claim 3, and wherein said portion of said sample carrier with said sample is cut out entirely and transferred into said vial.

6. The assembly of claim 3, and wherein said portion of said sample carrier with said sample is cut out only partly and means are provided for swinging down said cut out portion in said range of said vial and means are provided for flushing said sample from said sample carrier with said fluid from said high pressure fluid source into said vial.

7. The assembly of claim 3, and wherein said sample has a color, a degree of dryness, a position, and extent and wherein a scanner is provided for scanning said color, said degree of dryness, said position of said sample, said extent of said sample and/or further optically detectable features of said sample.

8. The assembly of claim 1, and further comprising one or more dispenser systems with a dispensing exit for adding reagents for said sample preparation from a reservoir, wherein said dispensing exit is fixed above said vials moving in said carousel whereby said reagent can be individually introduced into selected vials.

9. The assembly of claim 1, and further comprising a device for sealing a vial present in a receptacle in said carousel with a foil from a foil dispenser.

10. The assembly of claim 9, and further comprising a foil dispenser with foil and means for placing said foil from said foil dispenser above said vial;

a male form movably arranged above said vial; and

a heating means for heating said male form in a range of said upper edge of said vial in such a way that said foil is welded to said edge upon pressing said male form onto said edge;

wherein said male form exerts a pressure on said vial when said vial is sealed.

11. The assembly of claim 1, and wherein one station is formed by a male form and a Vortex-mixer below said vial and said vial is configured to be pressed on said Vortex-mixer with said male form movably arranged above said vial.

12. The assembly of claim 10, and wherein a Vortex-mixer is provided below said vial and said vial with said receptacle is configured to be moved between said male form and said Vortex-mixer.

13. The assembly of claim 1, and wherein a heating means for heating one or more vials is provided in said carousel.

14. The assembly of claim 1, and wherein means are provided for expelling solvent from a vial in a receptacle in said carousel by means of a gas.

15. The assembly of claim 1, and wherein said sample taking device for providing said sample for said analytic method comprises:

a suction device; and

a needle or tube connected to said suction device;

a filter inside said needle or tube;

a depot with a plurality of unused needles or tubes; and

means for exchanging said needle or tube after receiving said sample liquid and introducing said sample liquid in an analytic instrument by an unused needle or tube from said depot.

16. The assembly of claim 1, and wherein said sample liquid is present in said vial with a liquid supernatant with a depth above a solid state phase and a needle provided at said sampling device is configured to be inserted into said sample liquid with an end of said needle and the assembly further comprising optical means for the detection of said depth of said liquid supernatant and means for controlling said insertion depth of said end of said needle of said depth of said liquid supernatant.

17. The assembly of claim 1, and further comprising a reader at said carousel for reading identification data and/or data for said required sample preparation from a bar code, RFID-storage or any other data storage provided at said sample or vial.

18. The assembly of claim 1, and wherein an interface for connecting a HPLC-column, a gas chromatographic column or any other analytical instrument is provided downline said sampling device.

19. The assembly of claim 18, and wherein the carousal has a bottom and an opening is provided in the range of said receptacles for vials provided at said centrifuge in said bottom of said carousel which connects said carousel to a waste container.