Method, system and computer program for determining the porosity of a flexible porous structure subjected to deformation

• US 10,521,553 B2
• Filed: 01/25/2016
• Issued: 12/31/2019
• Est. Priority Date: 01/26/2015
• Status: Active Grant

• Current Assignee: Mentice AB
• Original Assignee: Galgo Medical SL
• Inventors: Serra del Molino, Luis, Larrabide Fernandez, Ignacio, Fernandez Martinez, Hector
• Primary Examiner(s): Huynh, Phuong
• Application Number:
  US15/545,902
• Publication Number:
  US 20180336310A1
• Time in Patent Office: 1,436 Days
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: G01N 15/088 Investigating volume, surface area, size or distribution of pores; Porosimetry
• CPC Class Codes: G16C 20/00 Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

A method, system and computer program are provided for determining the porosity of a flexible porous structure when it is subjected to deformation. The method performs the following steps by processing representative data of the flexible porous structure: a) generates a first function (F_s) defining how the flexible porous structure changes shape when it is subjected to deformation; b) generates a second function (F_p) defining how a covered surface of the flexible porous structure changes when it is subjected to changes in shape, wherein the second function (F_p) is directly linked with porosity of the flexible porous structure; c) obtains reference porosity values of a reference region (CU-R) of the flexible porous structure in a reference configuration via the first function (F_s); and d) calculates the porosity of at least one deformed region (CU-D) of the flexible porous structure, from said reference porosity values and from the second function (F_p).

Claims

1. A method for determining the porosity of a flexible porous structure when it is subjected to deformation, comprising performing the following steps by means of processing representative data of said flexible porous structure:

a) generating a first function (F_s) defining how at least one part of the flexible porous structure, given its coordinates, changes shape when it is subjected to one or more geometric deformations, wherein said change of the shape is determined in two directions, one in a cross-section of the flexible porous structure (F_s1) and the other in a longitudinal direction (F_s2);

b) generating a second function (F_p) defining how a covered surface, and/or a variable associated with same, for at least one part of the flexible porous structure, changes when it is subjected to one or more changes in shape, said second function (F_p) being directly linked with porosity of the flexible porous structure;

c) obtaining, by means of said first function (F_s), reference porosity values of at least one reference region (CU-R) of the flexible porous structure in a reference configuration; and

d) calculating the porosity of at least one deformed region (CU-D) of the flexible porous structure corresponding with said reference region (CU-R) but for a deformed configuration different from said reference configuration, from said obtained reference porosity values of the reference region (CU-R) and from at least said second function (F_p).

2. The method according to claim 1, wherein said data makes up respective three-dimensional representations of the flexible porous structure for each of the configurations:

the reference configuration and the deformed configuration,

wherein the data making up said three-dimensional representations are obtained by means of simulation or are obtained directly on a real flexible porous structure placed covering an outer surface of a solid or hollow element, or an inner surface demarcating a hollow region of an element.

3. The method according to claim 1, wherein said variable associated with porosity is relative to the occupancy of the material forming the flexible porous structure.

4. The method according to claim 1, wherein said variable associated with porosity is relative to the degree of interstitial space, or free space of the material forming the flexible porous structure.

5. The method according to claim 1, further comprising:

x1) selecting, before said step c), at least said deformed region (CU-D) of the flexible porous structure in said deformed configuration; and

x2) calculating, after said step c), the shape of at least said reference region (CU-R) of the flexible porous structure using said first function (F_s), using the coordinates corresponding to the deformed region (CU-D),

wherein said second function (F_p) generated in step b) defines how the occupancy of the material forming the flexible porous structure changes for at least said part of the flexible porous structure;

after said step x2) and prior to the calculation of porosity of the flexible porous structure in the deformed region (CU-D) of said step d), the method comprises calculating the occupancy of the material forming the flexible porous structure for at least said reference region (CU-R), from said reference porosity values; and

said step d) comprises;

d1) calculating the occupancy of the material forming the flexible porous structure for at least said deformed region (CU-D) using the second function (F_p) and the calculated occupancy of the reference region (CU-R); and

d2) calculating the porosity in the deformed region (CU-D) from said occupancy of same calculated in d1) and from its total dimension.

6. The method according to claim 5, wherein said step d2) comprises calculating the degree of interstitial space, or free space of the material forming the flexible porous structure, from said occupancy, and carrying out said calculation of porosity from said degree of interstitial space by calculating the quotient between interstitial space and total space of the deformed region (CU-D).

7. The method according to claim 1, wherein both said parts of the flexible porous structure and said deformed region (CU-D) and reference region (CU-R) are area elements on a perimetral surface of the flexible porous structure.

8. The method according to claim 1, wherein said flexible porous structure is tubular.

9. The method according to claim 8, wherein:

said first function (F_s) defines how a perimetral surface of the flexible porous structure changes shape when it is subjected to one or more geometric deformations; and

said second function (F_p) defines how the covered surface and/or said variable associated with same for the perimetral surface of the flexible porous structure, changes when it is subjected to one or more changes in shape.

10. The method according to claim 5, wherein:

the deformed regions (CU-D) are not superimposed on one another;

or

the deformed regions (CU-D) completely occupy a perimetral surface of the flexible porous structure, where the method comprises dividing said perimetral surface into said deformed regions (CU-D) prior to step x1).

11. The method according to claim 10, further comprising processing the several porosity values obtained in the corresponding steps d) to perform at least one of the following actions:

determining the spatial distribution of porosity throughout the flexible porous structure;

obtaining a porosity value combining at least several of said porosity values for a zone of the flexible porous structure that includes several deformed regions (CU-D); and

visually representing on a three-dimensional model of the flexible porous structure the spatial distribution of porosity for individual deformed regions (CU-D) and/or groups of deformed regions (CU-D),

Wherein the reference configuration corresponds to a situation in which the flexible porous structure is released into a medium in which it is not subject to external stresses deforming it, or wherein the reference configuration corresponds to a situation in which the flexible porous structure is deformed but with a reference deformation that is different from that of said deformed configuration.

12. The method according to claim 11, wherein said reference deformation is a deformation that keeps the flexible porous tubular structure straight and with a uniform radius along its entire length, wherein said flexible porous structure is tubular.

13. The method according to claim 1, wherein the flexible porous structure adopts, for said deformed configuration, a heterogeneous radius and a heterogeneous three-dimensional morphology, where said heterogeneous three-dimensional morphology includes at least one curvature and/or at least one twist.

14. The method according to claim 2, further comprising carrying out said calculation of porosity for several deformed spatial configurations, with different deformations, corresponding to several respective positions adopted by the flexible porous structure in said simulation or in relation to said element.

15. The method according to claim 1, wherein said flexible porous structure is a stent.

16. The method according to claim 1, wherein in said deformed configuration the flexible porous structure adopts a conical shape.

17. The method according to claim 1, wherein said reference porosity values of said reference region (CU-R) are known and are recorded in a memory, where the method performs said obtaining of said porosity values of said reference region (CU-R) by accessing same in said memory.

18. A system for determining the porosity of a flexible porous structure when it is subjected to deformation, comprising a data processing unit with access to reference porosity values of at least one reference region (CU-R) of the flexible porous structure in a reference configuration, and which implement an algorithm for processing representative data of said flexible porous structure for the calculation of porosity by:

a) generating a first function (F_s) defining how at least one part of the flexible porous structure, given its coordinates, changes shape when it is subjected to one or more geometric deformations, wherein said change of the shape is determined in two directions, one in the cross-section of the flexible porous structure (F_s1) and the other in the longitudinal direction (F_s2);

b) generating a second function (F_p) defining how a covered surface, and/or a variable associated with same, for at least one part of the flexible porous structure, changes when it is subjected to one or more changes in shape, said second function (F_p) being directly linked with porosity of the flexible porous structure;

c) obtaining, by means of said first function (F_s), reference porosity values of at least one reference region (CU-R) of the flexible porous structure in a reference configuration; and

d) calculating the porosity of at least one deformed region (CU-D) of the flexible porous structure corresponding with said reference region (CU-R) but for a deformed configuration different from said reference configuration, from said obtained reference porosity values of the reference region (CU-R) and from at least said second function (F_p).

19. The system according to claim 18, further comprising:

a computing unit including said processing unit;

a display unit configured for, under the control of said computing unit, showing a three-dimensional representation of the flexible porous structure for the deformed configuration with the spatial distribution of porosity calculated for individual deformed regions (CU-D) and/or groups of deformed regions (CU-D),

wherein the computing unit being further configured for carrying out said calculation of porosity for several deformed configurations, with different deformations, corresponding to several respective positions adopted by the flexible porous structure, and for controlling the display unit so that they show a three-dimensional representation of the flexible porous structure for said deformed configurations with their respective spatial distributions of porosity for individual deformed regions (CU-D) and/or groups of deformed regions (CU-D).

20. A computer program product including code instructions which when they are run in a computer implement a method for determining the porosity of a flexible porous structure when it is subjected to deformation by performing the following steps:

a) generating a first function (F_s) defining how at least one part of the flexible porous structure, given its coordinates, changes shape when it is subjected to one or more geometric deformations, wherein said change of the shape is determined in two directions, one in the cross-section of the flexible porous structure (F_s1) and the other in the longitudinal direction (F_s2);

b) generating a second function (F_p) defining how a covered surface, and/or a variable associated with same, for at least one part of the flexible porous structure, changes when it is subjected to one or more changes in shape, said second function (F_p) being directly linked with porosity of the flexible porous structure;

c) obtaining, by means of said first function (F_s), reference porosity values of at least one reference region (CU-R) of the flexible porous structure in a reference configuration; and

d) calculating the porosity of at least one deformed region (CU-D) of the flexible porous structure corresponding with said reference region (CU-R) but for a deformed configuration different from said reference configuration, from said obtained reference porosity values of the reference region (CU-R) and from at least said second function (F_p).