Method and control device for controlling the administration of insulin to a patient
First Claim
1. A method for controlling the administration of insulin to a patient, comprising:
- setting a target glucose level,computing, using a controller, a recommended infusion rate for administering insulin to the patient based on the target glucose level and a measured glucose level of the patient determined using a sensor device, wherein the controller uses a controller gain for computing the recommended infusion rate,determining an insulin sensitivity of the patient using a mathematical model based on the measured glucose level and an actual infusion rate of insulin administered to the patient,determining, based on the insulin sensitivity, the controller gain of the controller, wherein the controller gain for computing the recommended infusion rate is determined by associating the insulin sensitivity to one of a plurality of predefined insulin sensitivity classes, each insulin sensitivity class having boundaries defined by measures of stability and robustness related to controller behavior and being associated with a predefined controller gain such that by associating the insulin sensitivity to an insulin sensitivity class, the controller gain is determined to be the controller gain of the associated insulin sensitivity class, wherein each insulin sensitivity class is defined by associated ranges of a stability parameter and a robustness parameter determined based on the insulin sensitivity, andadministering insulin at the recommended infusion rate to the patient using an infusion pump.
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Abstract
In a method for controlling the administration of insulin to a patient, a target glucose level is set and a controller computes a recommended infusion rate based on the target glucose level and a measured glucose level of a patient for administering insulin to the patient. The controller uses a controller gain for computing the recommended infusion rate. Herein, an insulin sensitivity of the patient is determined using a mathematical model taking into account the measured glucose level and an actual infusion rate of insulin administered to the patient and, based on the insulin sensitivity, the controller gain of the controller is determined. In this way a method for controlling the administration of insulin to a patient is provided which in a reliable, computationally efficient manner allows for maintaining a patient'"'"'s blood glucose level at or around a desired target glucose level.
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Citations
16 Claims
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1. A method for controlling the administration of insulin to a patient, comprising:
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setting a target glucose level, computing, using a controller, a recommended infusion rate for administering insulin to the patient based on the target glucose level and a measured glucose level of the patient determined using a sensor device, wherein the controller uses a controller gain for computing the recommended infusion rate, determining an insulin sensitivity of the patient using a mathematical model based on the measured glucose level and an actual infusion rate of insulin administered to the patient, determining, based on the insulin sensitivity, the controller gain of the controller, wherein the controller gain for computing the recommended infusion rate is determined by associating the insulin sensitivity to one of a plurality of predefined insulin sensitivity classes, each insulin sensitivity class having boundaries defined by measures of stability and robustness related to controller behavior and being associated with a predefined controller gain such that by associating the insulin sensitivity to an insulin sensitivity class, the controller gain is determined to be the controller gain of the associated insulin sensitivity class, wherein each insulin sensitivity class is defined by associated ranges of a stability parameter and a robustness parameter determined based on the insulin sensitivity, and administering insulin at the recommended infusion rate to the patient using an infusion pump. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A control device for controlling the administration of insulin to a patient, comprising:
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a target setting unit for setting a target glucose level, a controller for computing a recommended infusion rate for administering insulin to the patient based on the target glucose level and a measured glucose level of the patient using a sensor device, wherein the controller uses a controller gain for computing the recommended infusion rate, a model unit configured to determine an insulin sensitivity of the patient with a mathematical model based on the measured glucose level and an actual infusion rate of insulin administered to the patient and an adaption unit for determining based on the insulin sensitivity, the controller gain of the controller, wherein the adaption unit is configured to determine the controller gain for computing the recommended infusion rate by associating the insulin sensitivity to one of a plurality of predefined insulin sensitivity classes, each insulin sensitivity class having boundaries defined by measures of stability and robustness related to controller behavior and being associated with a predefined controller gain such that by associating the insulin sensitivity to an insulin sensitivity class, the controller gain is determined to be the controller gain of the associated insulin sensitivity class, wherein each insulin sensitivity class is defined by associated ranges of a stability parameter and a robustness parameter determined based on the insulin sensitivity; and an output connectable to an infusion pump for administering insulin at the recommended infusion rate to the patient to feed the infusion pump the recommended infusion rate. - View Dependent Claims (15, 16)
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Specification