×

Hydrogel-forming peptides

  • US 10,526,371 B2
  • Filed: 07/13/2016
  • Issued: 01/07/2020
  • Est. Priority Date: 07/13/2015
  • Status: Active Grant
First Claim
Patent Images

1. A hydrogel-forming peptide comprising from 5 to 12 amino acid residues,wherein the amino acid residues are selected from hydrophobic and hydrophilic amino acid residues;

  • wherein the hydrophobic amino acid residues are independently selected from alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, tryptophan and cyclohexylalanine;

    wherein the hydrophilic amino acid residues are independently selected from asparagine, glutamine, arginine, histidine, lysine, ornithine, aspartic acid and glutamic acid;

    wherein the peptide further comprises one, two, or three dyads of hydrophobic amino acid residues, wherein at least one dyad contains a β

    -homo amino acid residue;

    wherein each dyad is separated from any other dyad or hydrophobic amino acid residue by a hydrophilic amino acid residue;

    wherein the amino acid residues that are not a β

    -homo amino acid residue are α

    -amino acid residues;

    wherein the N-terminus of the hydrogel-forming peptide;

    bears two Ra groups each independently selected from R1, orbears one R1 group and one group selected from C(═

    Z)R1, C(═

    Z)ZR1, C(═

    Z)NHR1 and C(═

    Z)N(R1)2;

    wherein each Z independently is O or S; and

    each R1 is independently selected from H, optionally substituted linear or branched C1-10alkyl, optionally substituted C3-10cycloalkyl, optionally substituted arylC1-6alkyl and optionally substituted aryl;

    wherein the C-terminus of the hydrogen forming peptide forms a group C(═

    O)OR2 or C(═

    O)N(R2)2; and

    wherein each R2 independently is selected from H, optionally substituted linear or branched C1-10alkyl, optionally substituted C3-10cycloalkyl, optionally substituted arylC1-6alkyl, and optionally substituted aryl;

    or a salt form thereof.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×