Hydrogel-forming peptides
First Claim
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1. A hydrogel-forming peptide comprising from 5 to 12 amino acid residues,wherein the amino acid residues are selected from hydrophobic and hydrophilic amino acid residues;
- wherein the hydrophobic amino acid residues are independently selected from alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, tryptophan and cyclohexylalanine;
wherein the hydrophilic amino acid residues are independently selected from asparagine, glutamine, arginine, histidine, lysine, ornithine, aspartic acid and glutamic acid;
wherein the peptide further comprises one, two, or three dyads of hydrophobic amino acid residues, wherein at least one dyad contains a β
-homo amino acid residue;
wherein each dyad is separated from any other dyad or hydrophobic amino acid residue by a hydrophilic amino acid residue;
wherein the amino acid residues that are not a β
-homo amino acid residue are α
-amino acid residues;
wherein the N-terminus of the hydrogel-forming peptide;
bears two Ra groups each independently selected from R1, orbears one R1 group and one group selected from C(═
Z)R1, C(═
Z)ZR1, C(═
Z)NHR1 and C(═
Z)N(R1)2;
wherein each Z independently is O or S; and
each R1 is independently selected from H, optionally substituted linear or branched C1-10alkyl, optionally substituted C3-10cycloalkyl, optionally substituted arylC1-6alkyl and optionally substituted aryl;
wherein the C-terminus of the hydrogen forming peptide forms a group C(═
O)OR2 or C(═
O)N(R2)2; and
wherein each R2 independently is selected from H, optionally substituted linear or branched C1-10alkyl, optionally substituted C3-10cycloalkyl, optionally substituted arylC1-6alkyl, and optionally substituted aryl;
or a salt form thereof.
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Abstract
Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a β3- or β2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.
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Citations
15 Claims
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1. A hydrogel-forming peptide comprising from 5 to 12 amino acid residues,
wherein the amino acid residues are selected from hydrophobic and hydrophilic amino acid residues; -
wherein the hydrophobic amino acid residues are independently selected from alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, tryptophan and cyclohexylalanine; wherein the hydrophilic amino acid residues are independently selected from asparagine, glutamine, arginine, histidine, lysine, ornithine, aspartic acid and glutamic acid; wherein the peptide further comprises one, two, or three dyads of hydrophobic amino acid residues, wherein at least one dyad contains a β
-homo amino acid residue;wherein each dyad is separated from any other dyad or hydrophobic amino acid residue by a hydrophilic amino acid residue; wherein the amino acid residues that are not a β
-homo amino acid residue are α
-amino acid residues;wherein the N-terminus of the hydrogel-forming peptide; bears two Ra groups each independently selected from R1, or bears one R1 group and one group selected from C(═
Z)R1, C(═
Z)ZR1, C(═
Z)NHR1 and C(═
Z)N(R1)2;wherein each Z independently is O or S; and
each R1 is independently selected from H, optionally substituted linear or branched C1-10alkyl, optionally substituted C3-10cycloalkyl, optionally substituted arylC1-6alkyl and optionally substituted aryl;wherein the C-terminus of the hydrogen forming peptide forms a group C(═
O)OR2 or C(═
O)N(R2)2; andwherein each R2 independently is selected from H, optionally substituted linear or branched C1-10alkyl, optionally substituted C3-10cycloalkyl, optionally substituted arylC1-6alkyl, and optionally substituted aryl; or a salt form thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification