Multiband, multishot magnetic resonance elastography

• US 10,527,700 B2
• Filed: 10/18/2017
• Issued: 01/07/2020
• Est. Priority Date: 10/19/2016
• Status: Active Grant

• Current Assignee: Board of Trustees of The University of Illinois
• Original Assignee: Board of Trustees of The University of Illinois
• Inventors: Johnson, Curtis L., Sutton, Bradley P., Holtrop, Joseph L.
• Primary Examiner(s): Patel, Paresh H
• Application Number:
  US15/787,462
• Publication Number:
  US 20180106879A1
• Time in Patent Office: 811 Days
• Field of Search: None
• CPC Class Codes: G01R 33/4826 in three dimensions
• CPC Class Codes: G01R 33/4835 of multiple slices
• CPC Class Codes: G01R 33/5611 Parallel magnetic resonance imaging, e.g. sensitivity encoding [SENSE], simultaneous acquisition of spatial harmonics [SMASH], unaliasing by Fourier encoding of the overlaps using the temporal dimension [UNFOLD], k-t-broad-use linear acquisition speed-up technique [k-t-BLAST], k-t-SENSE structural details of arrays of sub-coils G01R33/3415
• CPC Class Codes: G01R 33/56358 Elastography
• CPC Class Codes: G01R 33/5673 Gating or triggering based on a physiological signal other than an MR signal, e.g. ECG gating or motion monitoring using optical systems for monitoring the motion of a fiducial marker
• CPC Class Codes: G01R 33/5676 Gating or triggering based on an MR signal, e.g. involving one or more navigator echoes for motion monitoring and correction

Abstract

A method and system provides an acquisition scheme for generating magnetic resonance elastography displacement data with whole-sample coverage, high spatial resolution, and adequate SNR in a short scan time. The method and system can acquire in-plane and through-plane k-space shots over a volume of a sample divided into a plurality of slabs that each include a plurality of non-adjacent slices to obtain three dimensional multiband, multishot data, can apply multiband radio frequency refocusing pulses to the sample, can acquire navigators before readout, and can correct for non-linear motion errors.

Claims

1. A method of magnetic resonance elastography, the method comprising:

applying, by a system including a processor, a multiband radio frequency (RF) excitation pulse to a sample, wherein the sample is divided into a plurality of slabs that each include a plurality of non-adjacent slices;

applying, by the system, first and second motion encoding gradients and a multiband RF refocusing pulse to the sample, wherein the first motion encoding gradient is applied before the multiband RF refocusing pulse, and wherein the second motion encoding gradient is applied after the multiband RF refocusing pulse;

acquiring, by the system, a blipped, spiral-in three dimensional navigator data;

providing, by the system, a gradient blip normal to the non-adjacent slices to define a sample plane;

acquiring, by the system, in-plane k-space data after the second motion encoding gradient is applied and after the gradient blip is provided; and

repeating the applying of the multiband RF excitation pulse, the applying of the first and second motion encoding gradients and the multiband RF refocusing pulse, and the acquiring of the in-plane k-space data over the plurality of slabs to obtain three dimensional multiband, multishot data.

2. The method of claim 1, comprising generating a modulus map image for the sample according to the three dimensional multiband, multishot data.

3. The method of claim 1, comprising:

determining a relaxation time for the sample; and

calculating a repetition time according to the relaxation time, wherein the three dimensional multiband, multishot data is obtained according to the repetition time.

4. The method of claim 1, comprising:

performing, by the system, non-linear motion correction for phase errors, the non-linear motion correction being performed based on the spiral-in three dimensional navigator data.

5. The method of claim 4, wherein the acquiring of the spiral-in three dimensional navigator data is repeated over the plurality of slabs of the sample to acquire a plurality of navigators, wherein the non-linear motion correction is performed based on the plurality of navigators.

6. The method of claim 5, comprising:

averaging the plurality of navigators, wherein the non-linear motion correction for the phase errors is performed based on phase errors determined by comparing each navigator with an average of the plurality of navigators.

7. The method of claim 1, wherein a total number of excitations is equal to a number of acquired in-plane k-space shots times a number of slices per slab, and wherein the first and second motion encoding gradients are flow-compensated.

8. The method of claim 1, wherein the three dimensional multiband, multishot data is obtained utilizing parallel imaging by undersampling.

9. The method of claim 8, wherein the undersampling comprises in-plane undersampling and through-plane undersampling.

10. The method of claim 1, wherein the sample is an in vivo brain, wherein the plurality of non-adjacent slices of consecutive slabs are interleaved.

11. A system comprising:

an actuator for applying a vibration to a sample;

a magnetic resonance system for facilitating applying magnetic resonance elastography to the sample;

a processor coupled with the actuator and the magnetic resonance system; and

a memory that stores executable instructions which, responsive to being executed by the processor, facilitate performance of operations, comprising;

applying first and second motion encoding gradients and a multiband radio frequency (RF) excitation pulse to the sample, wherein the multiband RF excitation pulse is applied before the first motion encoding gradient, and wherein the second motion encoding gradient is applied after a multiband RF refocusing pulse;

acquiring a blipped, spiral-in three dimensional navigator data;

providing a gradient blip to define a sample plane;

acquiring in-plane k-space data after the gradient blip is provided; and

repeating the applying of the multiband RF excitation pulse, the first and second motion encoding gradients, the multiband RF refocusing pulse and the acquiring of the in-plane k-space data over a plurality of slabs comprising non-adjacent slices to obtain three dimensional multiband, multishot data.

12. The system of claim 11, wherein the operations further comprise generating a modulus map image for the sample according to the three dimensional multiband, multishot data.

13. The system of claim 11, wherein the operations further comprise performing non-linear motion correction for phase errors, the non-linear motion correction being performed based on the spiral-in three dimensional navigator data.

14. The system of claim 11, wherein the three dimensional multiband, multishot data is obtained utilizing parallel imaging by in-plane and through-plane undersampling.

15. The system of claim 11, wherein the non-adjacent slices of consecutive slabs are interleaved.

16. A computer-readable storage device comprising computer instructions which, responsive to being executed by a processor, facilitate performance of operations, comprising:

applying a multiband radio frequency (RF) excitation pulse to a sample that is divided into a plurality of slabs that each include a plurality of non-adjacent slices;

applying first and second motion encoding gradients and a multiband RF refocusing pulse to the sample, wherein the first motion encoding gradient is applied before the multiband RF refocusing pulse and the second motion encoding gradient is applied after the multiband RF refocusing pulse;

acquiring a blipped, spiral-in three dimensional navigator data;

providing an encoded gradient blip to define a sample plane;

acquiring an in-plane k-space shot comprising the plurality of non-adjacent slices after the second motion encoding gradient is applied; and

repeating the applying of the multiband RF excitation pulse, the applying of the first and second motion encoding gradients and the multiband RF refocusing pulse, and the acquiring of the spiral-in three dimensional navigator data and the in-plane k-space shot over the plurality of slabs of the sample to obtain three dimensional multiband, multishot data.

17. The computer-readable storage device of claim 16, wherein the operations further comprise:

determining a relaxation time for the sample; and

calculating a repetition time according to the relaxation time to achieve a high signal-to-noise ratio efficiency, wherein the three dimensional multiband, multishot data is obtained according to the repetition time.

18. The computer-readable storage device of claim 16, wherein the operations further comprise:

correcting for non-linear motion phase errors based on the blipped, spiral-in three dimensional navigator data acquired.

19. The computer-readable storage device of claim 16, wherein the plurality of non-adjacent slices between consecutive slabs are interleaved.

20. The computer-readable storage device of claim 16, wherein the three dimensional multiband, multishot data is obtained utilizing parallel imaging of the sample by in-plane and through-plane undersampling.