Real-time phase detection of frequency band

• US 10,529,450 B2
• Filed: 08/07/2018
• Issued: 01/07/2020
• Est. Priority Date: 11/21/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Corey, Robert A., Loxtercamp, Gregory J., Orser, Heather Diane, Stanslaski, Scott R., Jackson, Jadin C.
• Primary Examiner(s): Sengdara, Vongsavanh
• Application Number:
  US16/057,417
• Publication Number:
  US 20180350465A1
• Time in Patent Office: 518 Days
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: G16H 40/63 for local operation

Abstract

Techniques are described for real-time phase detection. For the phase detection, a signal is correlated with a frequency component of a frequency band whose phase is being detected, and the correlation includes predominantly decreasing weighting of past portions of the signals.

Claims

1. A method comprising:

receiving, with circuitry of a medical device, a first signal generated from a second signal;

correlating, with the circuitry of the medical device, the first signal with a set of frequency components of a frequency band of the second signal in order to generate a filtered signal, wherein correlating the first signal with the set of frequency components comprises;

correlating the first signal with a set of waveforms of a periodic basis set, wherein each waveform of the set of waveforms corresponds to a respective frequency component of the set of frequency components such that a frequency of each waveform of the set of waveforms of the periodic basis set is the respective frequency component of the set of frequency components, and

weighting relatively more recent portions of the first signal more heavily than relatively less recent portions of the first signal as part of correlating the first signal with the set of waveforms of the periodic basis set;

determining a phase of the frequency band based on the filtered signal;

instructing, with the circuitry of the medical device, a therapy module to deliver therapy based on the phase of the frequency band; and

delivering, with the therapy module, the therapy.

2. The method of claim 1, further comprising:

identifying, with the circuitry of the medical device, a region of a group of regions based on the phase of the frequency band, wherein the group of regions comprises at least one peak region and at least one trough region,

wherein instructing the therapy module to deliver therapy comprises instructing the therapy module to delivery therapy based on the phase of the frequency band and the region of the group of regions.

3. The method of claim 2, wherein instructing the therapy module to deliver therapy comprises instructing the therapy module to deliver electrical stimulation during the at least one peak region, and wherein the phase of the frequency band is about 90 degrees during the at least one peak region.

4. The method of claim 2, wherein instructing the therapy module to deliver therapy comprises instructing the therapy module to deliver electrical stimulation during the at least one trough region, and wherein the phase of the frequency band is about 270 degrees during the at least one trough region.

5. The method of claim 1, wherein determining the phase of the frequency band comprises:

determining, with the circuitry of the medical device, a phase of each frequency component of the set of frequency components based on the filtered signal outputted from the correlation; and

determining, with the circuitry of the medical device, the phase of the frequency band based on the phase of each respective frequency component of the set of frequency components.

6. The method of claim 1, wherein the first signal is one of:

the second signal pre-filtered to generate the first signal;

or

the same as the second signal.

7. The method of claim 1, further comprising:

determining, for each frequency component of the set of frequency components, a frequency weighting based on the filtered signal,

wherein determining the phase of the frequency band comprises determining the phase of the frequency band based on a phase corresponding to each frequency component of the set of frequency components and the frequency weighting corresponding to each frequency component of the set of frequency components.

8. The method of claim 1, wherein determining the phase of the frequency band comprises:

adding or subtracting a phase delay caused from generating the first signal from the second signal to the phase of the frequency component; and

determining the phase of the frequency band based on a result of adding or subtracting the phase delay.

9. The method of claim 1, wherein the set of waveforms of the periodic basis set include a sine wave and a cosine wave.

10. The method of claim 1, wherein correlating the first signal with the set of frequency components of the frequency band of the second signal further comprises:

Fourier transforming the first signal with an exponentially decreasing weighting of past portions of the first signal.

11. The method of claim 1, further comprising determining a phase of each frequency component of the set of frequency components in real-time, and wherein determining the phase of the frequency band comprises determining the phase of the frequency band in real-time based on the phase of each frequency component of the set of frequency components.

12. A medical device comprising:

a frequency band phase detector comprising;

a frequency component phase detector configured to;

receive a first signal generated from a second signal; and

correlate the first signal with a set of frequency components of a frequency band of the second signal in order to generate a filtered signal, wherein to correlate the first signal with the set of frequency components, the frequency component phase detector is configured to;

correlate the first signal with a set of waveforms of a periodic basis set, wherein each waveform of the set of waveforms corresponds to a respective frequency component of the set of frequency components such that a frequency of each waveform of the set of waveforms of the periodic basis set is the respective frequency component of the set of frequency components, and

weight relatively more recent portions of the first signal more heavily than relatively less recent portions of the first signal as part of correlating the first signal with the set of waveforms of the periodic basis set;

an averager configured to determine a phase of the frequency band based on the filtered signal; and

a therapy module configured to deliver therapy based on the phase of the frequency band.

13. The medical device of claim 12, further comprising circuitry configured to:

identify a region of a group of regions based on the phase of the frequency band, wherein the group of regions comprises at least one peak region and at least one trough region,

wherein the therapy module is configured to delivery therapy based on the phase of the frequency band and the region of the group of regions.

14. The medical device of claim 13, wherein the therapy module is configured to deliver therapy by delivering electrical stimulation during the at least one peak region, and wherein the phase of the frequency band is about 90 degrees during the at least one peak region.

15. The medical device of claim 13, wherein the therapy module is configured to deliver therapy by delivering electrical stimulation during the at least one trough region, and wherein the phase of the frequency band is about 270 degrees during the at least one trough region.

16. The medical device of claim 12, wherein the first signal is one of:

the second signal pre-filtered to generate the first signal;

or

the same as the second signal.

17. The medical device of claim 12, wherein the frequency band phase detector is configured to:

determine, for each frequency component of the set of frequency components, a frequency weighting based on the filtered signal,

wherein to determine the phase of the frequency band, the averager is configured to determine the phase of the frequency band based on a phase corresponding to each frequency component of the set of frequency components and the frequency weighting corresponding to each frequency component of the set of frequency components.

18. The medical device of claim 12, wherein at least one of the frequency component phase detector or the averager is configured to add or subtract a phase delay caused from generating the first signal from the second signal to the phase of the frequency component, and wherein the averager is configured to determine the phase of the frequency band based on a result of adding or subtracting the phase delay.

19. The medical device of claim 12, wherein the set of waveforms of the periodic basis set include a sine wave and a cosine wave.

20. A non-transitory computer-readable storage medium comprising instructions that when executed cause one or more processors of a medical device to:

receive a first signal generated from a second signal;

correlate the first signal with a set of frequency components of a frequency band of the second signal in order to generate a filtered signal, wherein the instructions that cause the one or more processors to correlate the first signal with the set of frequency components comprise instructions that cause the one or more processors to;

correlate the first signal with a set of waveforms of a periodic basis set, wherein each waveform of the set of waveforms corresponds to a respective frequency component of the set of frequency components such that a frequency of each waveform of the set of waveforms of the periodic basis set is the respective frequency component of the set of frequency components, and

weight relatively more recent portions of the first signal more heavily than relatively less recent portions of the first signal as part of correlating the first signal with the set of waveforms of the periodic basis set;

determine a phase of the frequency band based on the filtered signal; and

instruct a therapy module to deliver therapy based on the phase of the frequency band,

wherein the therapy module is configured to deliver the therapy.