×

Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel

  • US 10,532,045 B2
  • Filed: 12/18/2014
  • Issued: 01/14/2020
  • Est. Priority Date: 12/18/2013
  • Status: Active Grant
First Claim
Patent Images

1. A composition for treating or preventing one or more cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns, or both, in a human or animal subject consisting of:

  • one or more pharmacologically active agents provided in an amount that inhibits the activity of an ether-a-go-go-related gene (hERG), wherein the one or more pharmacologically active agents are kinase inhibitors selected from crizotinib and nilotinib, wherein the amount of the one or more pharmacologically active agents is sufficient to treat a cancer, wherein the cancer is selected from non-small cell lung cancer or chronic myeloid leukemia;

    one or more empty liposomes, wherein the empty liposomes are administered prior to, concomitantly, or after administration of the pharmacologically active agent, wherein the one or more empty liposomes are provided in an amount effective to reduce the cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns, and the empty liposomes consist of at least one liposome selected from at least one of phosphatidylserine, phosphatidylinositol, sphingomyelin, cardiolipin, phosphatidic acid, cerebrosides, dicetylphosphate, dipalmitoyl-phosphatidylglycerol, stearylamine, dodecylamine, hexadecyl-amine, acetyl palmitate, glycerol ricinoleate, hexadecyl sterate, isopropyl myristate, amphoteric acrylic polymers, fatty acid, fatty acid amides, diacylglycerol, diacylglycerolsuccinate, DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine), or DMPG (1,2-dimyristoyl-sn-glycero-3-phospho-rac-[1-glycerol]).

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×